Linked Life Data

12091373

Source:http://linkedlifedata.com/resource/pubmed/id/12091373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-7-1
pubmed:abstractText
Using immunohistochemistry, we investigated the expression of c-mpl in bone marrow megakaryocytes of 88 patients with essential thrombocythemia (ET), 6 patients with secondary thrombocytosis (ST), and 20 patients with lymphoma (controls). Considering both the pattern of expression and the staining intensity, we identified a uniform and a heterogeneous pattern of c-mpl expression. The uniform pattern was found in all the controls, all the patients with ST, and 28 of the patients with ET, with a strong staining intensity observed in most megakaryocytes (> 80%). In contrast, c-mpl expression was heterogeneous in 60 patients with ET, 18 of whom (30%) presented with thrombosis at diagnosis, a significant difference from patients with a uniform c-mpl pattern (2 of 28; 7%; P =.026). In particular, the overrepresentation of thrombotic complications in patients with a heterogeneous c-mpl expression pattern was found mainly among patients with a significant percentage (10% to 40%) of weakly stained or c-mpl-negative megakaryocytes (heterogeneous-weak pattern; 13 of 30; 43%; P =.002). Accordingly, this pattern was associated with a 6.1-fold increased risk of thrombosis compared with that of patients with a uniform c-mpl pattern. In conclusion, the presence of a heterogeneous pattern of c-mpl distribution in bone marrow megakaryocytes could be a useful diagnostic criterion in the differential diagnosis of thrombocytosis. Furthermore, detection of a significant percentage of weakly stained or c-mpl-negative megakaryocytes can identify patients with a higher risk of thrombosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
714-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12091373-Adolescent, pubmed-meshheading:12091373-Adult, pubmed-meshheading:12091373-Aged, pubmed-meshheading:12091373-Aged, 80 and over, pubmed-meshheading:12091373-Female, pubmed-meshheading:12091373-Humans, pubmed-meshheading:12091373-Immunohistochemistry, pubmed-meshheading:12091373-Male, pubmed-meshheading:12091373-Megakaryocytes, pubmed-meshheading:12091373-Middle Aged, pubmed-meshheading:12091373-Neoplasm Proteins, pubmed-meshheading:12091373-Prognosis, pubmed-meshheading:12091373-Proto-Oncogene Proteins, pubmed-meshheading:12091373-Receptors, Cytokine, pubmed-meshheading:12091373-Receptors, Thrombopoietin, pubmed-meshheading:12091373-Retrospective Studies, pubmed-meshheading:12091373-Risk Factors, pubmed-meshheading:12091373-Thrombocythemia, Essential, pubmed-meshheading:12091373-Thrombosis
pubmed:year
2002
pubmed:articleTitle
The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia.
pubmed:affiliation
Department of Hematology, Catholic University, Rome, Italy. lteofili@rm.unicatt.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't