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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0020971,
umls-concept:C0032136,
umls-concept:C0033684,
umls-concept:C0034493,
umls-concept:C0035638,
umls-concept:C0042769,
umls-concept:C0205373,
umls-concept:C0331858,
umls-concept:C0679058,
umls-concept:C1280500,
umls-concept:C1547699,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C2700640
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2002-7-1
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|
pubmed:abstractText |
Plasmid vaccine pBK-CMVMPILC113 expressing the matrix (M) gene of rinderpest virus was assessed for its potential to protect rabbits against a lethal viral challenge. Rabbits immunized with plasmids expressing the M gene were not protected when challenged with lapinized rinderpest virus, despite the production of anti-M antibodies, while rabbits immunized with rinderpest tissue culture vaccine were completely protected from a lethal challenge with lapinized rinderpest virus. The plasmid vaccine also had no significant effect on the lymphopenia in challenged rabbits. The results indicate that rinderpest M protein does not have a protective role in rinderpest infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
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pubmed:issn |
0165-7380
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-37
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12090294-Animals,
pubmed-meshheading:12090294-Blotting, Western,
pubmed-meshheading:12090294-Body Temperature,
pubmed-meshheading:12090294-Body Weight,
pubmed-meshheading:12090294-COS Cells,
pubmed-meshheading:12090294-Cercopithecus aethiops,
pubmed-meshheading:12090294-Female,
pubmed-meshheading:12090294-Immunization,
pubmed-meshheading:12090294-Lymphocyte Count,
pubmed-meshheading:12090294-Male,
pubmed-meshheading:12090294-Plasmids,
pubmed-meshheading:12090294-Rabbits,
pubmed-meshheading:12090294-Rinderpest,
pubmed-meshheading:12090294-Rinderpest virus,
pubmed-meshheading:12090294-Vaccines, DNA,
pubmed-meshheading:12090294-Vero Cells,
pubmed-meshheading:12090294-Viral Matrix Proteins,
pubmed-meshheading:12090294-Viral Vaccines
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|
pubmed:year |
2002
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|
pubmed:articleTitle |
Effect of immunization with plasmid DNA encoding for rinderpest virus matrix protein on systemic rinderpest virus infection in rabbits.
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|
pubmed:affiliation |
National Project on Rinderpest Eradication, Division of Biochemistry and Food Sciences, Indian Veterinary Research Institute, Izatnagar. bpahar@primate.ucdavis.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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