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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-7-29
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pubmed:abstractText |
Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary for mast cell degranulation. Lyn-deficiency enhanced Fyn-dependent signals and degranulation, but inhibited the calcium response. Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, Fc epsilon RI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Fyn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gab1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lat protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fyn,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Syk kinase,
http://linkedlifedata.com/resource/pubmed/chemical/lyn protein-tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
741-8
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:12089510-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12089510-Animals,
pubmed-meshheading:12089510-Carrier Proteins,
pubmed-meshheading:12089510-Cell Degranulation,
pubmed-meshheading:12089510-Crosses, Genetic,
pubmed-meshheading:12089510-Enzyme Precursors,
pubmed-meshheading:12089510-Female,
pubmed-meshheading:12089510-Immunoblotting,
pubmed-meshheading:12089510-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12089510-Male,
pubmed-meshheading:12089510-Mast Cells,
pubmed-meshheading:12089510-Membrane Proteins,
pubmed-meshheading:12089510-Mice,
pubmed-meshheading:12089510-Mice, Inbred C57BL,
pubmed-meshheading:12089510-Mice, Knockout,
pubmed-meshheading:12089510-Phosphoproteins,
pubmed-meshheading:12089510-Phosphorylation,
pubmed-meshheading:12089510-Precipitin Tests,
pubmed-meshheading:12089510-Protein-Tyrosine Kinases,
pubmed-meshheading:12089510-Proto-Oncogene Proteins,
pubmed-meshheading:12089510-Proto-Oncogene Proteins c-fyn,
pubmed-meshheading:12089510-Receptors, IgE,
pubmed-meshheading:12089510-Signal Transduction,
pubmed-meshheading:12089510-src-Family Kinases
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pubmed:year |
2002
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pubmed:articleTitle |
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
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pubmed:affiliation |
Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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