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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2002-7-10
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pubmed:abstractText |
We measured daily gene expression in heads of control and period mutant Drosophila by using oligonucleotide microarrays. In control flies, 72 genes showed diurnal rhythms in light-dark cycles; 22 of these also oscillated in free-running conditions. The period gene significantly influenced the expression levels of over 600 nonoscillating transcripts. Expression levels of several hundred genes also differed significantly between control flies kept in light-dark versus constant darkness but differed minimally between per(01) flies kept in the same two conditions. Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12089325-10442235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12089325-10442236,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12089325-9988221
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9562-7
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:12089325-Animals,
pubmed-meshheading:12089325-Circadian Rhythm,
pubmed-meshheading:12089325-Drosophila Proteins,
pubmed-meshheading:12089325-Drosophila melanogaster,
pubmed-meshheading:12089325-Gene Expression,
pubmed-meshheading:12089325-Gene Expression Profiling,
pubmed-meshheading:12089325-Genes, Insect,
pubmed-meshheading:12089325-Mutation,
pubmed-meshheading:12089325-Nuclear Proteins,
pubmed-meshheading:12089325-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12089325-Period Circadian Proteins,
pubmed-meshheading:12089325-Photoperiod
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pubmed:year |
2002
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pubmed:articleTitle |
Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.
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pubmed:affiliation |
Department of Genetics, Washington University Medical School, St. Louis, MO, 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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