Linked Life Data

12088740

Source:http://linkedlifedata.com/resource/pubmed/id/12088740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-6-28
pubmed:abstractText
We have investigated a potential mechanism by which a diet, similar in composition to the typical diet of most industrialized western societies rich in saturated fat and refined sugar (HFS), can influence brain structure and function via regulation of neurotrophins. We show that animals that learn a spatial memory task faster have more brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus. Two months on the HFS diet were sufficient to reduce hippocampal level of BDNF and spatial learning performance. Consequent to the action of BDNF on synaptic function, downstream effectors for the action of BDNF on synaptic plasticity were reduced proportionally to BDNF levels, in the hippocampus of rats maintained on the HFS diet between 2 and 24 months. In particular, animals maintained on the HFS diet showed a decrease in levels of: (i) synapsin I mRNA and protein (total and phosphorylated), important for neurotransmitter release; (ii) cyclic AMP-response element-binding protein (CREB) mRNA and protein (total and phosphorylated); CREB is required for various forms of memory and is under regulatory control of BDNF; (iii) growth-associated protein 43 mRNA, important for neurite outgrowth, neurotransmitter release, and learning and memory. Diet-related changes were specific for the hippocampus consequent to its role in memory formation, and did not involve neurotrophin-3, another member of the neurotrophin family. Our results indicate that a popularly consumed diet can influence crucial aspects of neuronal and behavioral plasticity associated with the function of BDNF.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
803-14
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:12088740-Animals, pubmed-meshheading:12088740-Brain-Derived Neurotrophic Factor, pubmed-meshheading:12088740-Cerebral Cortex, pubmed-meshheading:12088740-Cyclic AMP Response Element-Binding Protein, pubmed-meshheading:12088740-Dietary Fats, pubmed-meshheading:12088740-Dietary Sucrose, pubmed-meshheading:12088740-Female, pubmed-meshheading:12088740-GAP-43 Protein, pubmed-meshheading:12088740-Hippocampus, pubmed-meshheading:12088740-Immunohistochemistry, pubmed-meshheading:12088740-Learning, pubmed-meshheading:12088740-Neuronal Plasticity, pubmed-meshheading:12088740-RNA, Messenger, pubmed-meshheading:12088740-Rats, pubmed-meshheading:12088740-Rats, Inbred F344, pubmed-meshheading:12088740-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12088740-Synapsins
pubmed:year
2002
pubmed:articleTitle
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning.
pubmed:affiliation
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, 90095, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.