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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-6-28
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pubmed:abstractText |
Natural killer (NK) cells and interferon- (IFN) gamma have been implicated in immune surveillance against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors (L929, LB27.4, and Renca) but not TRAIL-resistant tumors (P815 and B16). Such a protective effect of TRAIL against TRAIL-sensitive tumors was abrogated in NK cell-depleted or IFN-gamma-deficient mice. These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Pore Forming Cytotoxic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
214
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-200
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12088418-Animals,
pubmed-meshheading:12088418-Antibodies, Monoclonal,
pubmed-meshheading:12088418-Apoptosis Regulatory Proteins,
pubmed-meshheading:12088418-Carcinoma, Renal Cell,
pubmed-meshheading:12088418-Cytotoxicity, Immunologic,
pubmed-meshheading:12088418-Fibrosarcoma,
pubmed-meshheading:12088418-Immunity, Innate,
pubmed-meshheading:12088418-Immunologic Surveillance,
pubmed-meshheading:12088418-Injections, Subcutaneous,
pubmed-meshheading:12088418-Interferon-gamma,
pubmed-meshheading:12088418-Kidney Neoplasms,
pubmed-meshheading:12088418-Killer Cells, Natural,
pubmed-meshheading:12088418-L Cells (Cell Line),
pubmed-meshheading:12088418-Male,
pubmed-meshheading:12088418-Mast-Cell Sarcoma,
pubmed-meshheading:12088418-Melanoma, Experimental,
pubmed-meshheading:12088418-Membrane Glycoproteins,
pubmed-meshheading:12088418-Mice,
pubmed-meshheading:12088418-Mice, Inbred BALB C,
pubmed-meshheading:12088418-Mice, Inbred C3H,
pubmed-meshheading:12088418-Mice, Inbred C57BL,
pubmed-meshheading:12088418-Mice, Knockout,
pubmed-meshheading:12088418-Mice, SCID,
pubmed-meshheading:12088418-Neoplasm Transplantation,
pubmed-meshheading:12088418-Neoplasms, Experimental,
pubmed-meshheading:12088418-Perforin,
pubmed-meshheading:12088418-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:12088418-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:12088418-Tumor Cells, Cultured,
pubmed-meshheading:12088418-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth.
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pubmed:affiliation |
Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. ktakeda@med.juntendo.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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