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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1976-3-11
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|
pubmed:abstractText |
Oral administration of ET-495 was found to cause worsening of psychiatric status in 4 out of 7 schizophrenic patients, and to induce a paranoid state and a syndrome of auditory hallucinosis in 2 non-schizophrenics. These observations were compatible with the hypothesized role of dopamine in schizophrenia. However, these psychotogenic effects were far less dramatic than those noted in other studies with amphetamine, methylphenidate or L-Dopa. Possible explanations for this differing psychotogenic potency of receptor stimulators versus presynaptic agonists are presented. Intravenous ET-495 and apomorphine did not show psychotogenic effects.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0033-3158
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
21
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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|
pubmed:pagination |
273-80
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:1208762-Adult,
pubmed-meshheading:1208762-Apomorphine,
pubmed-meshheading:1208762-Blood Pressure,
pubmed-meshheading:1208762-Dopamine,
pubmed-meshheading:1208762-Female,
pubmed-meshheading:1208762-Hallucinations,
pubmed-meshheading:1208762-Humans,
pubmed-meshheading:1208762-Male,
pubmed-meshheading:1208762-Metoclopramide,
pubmed-meshheading:1208762-Middle Aged,
pubmed-meshheading:1208762-Piperazines,
pubmed-meshheading:1208762-Piribedil,
pubmed-meshheading:1208762-Receptors, Drug,
pubmed-meshheading:1208762-Schizophrenia,
pubmed-meshheading:1208762-Schizophrenia, Paranoid,
pubmed-meshheading:1208762-Schizophrenic Psychology,
pubmed-meshheading:1208762-Stimulation, Chemical,
pubmed-meshheading:1208762-Vomiting
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|
pubmed:year |
1975
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|
pubmed:articleTitle |
Clinical studies with dopamine-receptor stimulants.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Case Reports
|
