| pubmed-article:12086888 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:12086888 | lifeskim:mentions | umls-concept:C1704788 | lld:lifeskim |
| pubmed-article:12086888 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12086888 | pubmed:dateCreated | 2002-6-27 | lld:pubmed |
| pubmed-article:12086888 | pubmed:abstractText | We have developed a mouse model for ovarian carcinoma by using an avian retroviral gene delivery technique for the introduction of multiple genes into somatic ovarian cells of adult mice. Ovarian cells from transgenic mice engineered to express the gene encoding the avian receptor TVA were efficiently infected in vitro with multiple vectors carrying coding sequences for oncogenes and marker genes. When target cells were derived from TVA transgenic mice deficient for p53, the addition of any two of the oncogenes c-myc, K-ras, and Akt were sufficient to induce ovarian tumor formation when infected cells were injected at subcutaneous, intraperitoneal, or ovarian sites. We demonstrated that the ovarian surface epithelium is the precursor tissue for these ovarian carcinomas, and that introduction of oncogenes causes phenotypic changes in the ovarian surface epithelial cells. The induced ovarian tumors in mice resembled human ovarian carcinomas in their rapid progression and intraperitoneal metastatic spread. | lld:pubmed |
| pubmed-article:12086888 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12086888 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086888 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12086888 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12086888 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:12086888 | pubmed:author | pubmed-author:LiYiY | lld:pubmed |
| pubmed-article:12086888 | pubmed:author | pubmed-author:GutkindJ... | lld:pubmed |
| pubmed-article:12086888 | pubmed:author | pubmed-author:SoslowRobert... | lld:pubmed |
| pubmed-article:12086888 | pubmed:author | pubmed-author:OrsulicSandra... | lld:pubmed |
| pubmed-article:12086888 | pubmed:author | pubmed-author:Vitale-CrossL... | lld:pubmed |
| pubmed-article:12086888 | pubmed:author | pubmed-author:VarmusHarold... | lld:pubmed |
| pubmed-article:12086888 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12086888 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:12086888 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12086888 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12086888 | pubmed:pagination | 53-62 | lld:pubmed |
| pubmed-article:12086888 | pubmed:dateRevised | 2011-6-15 | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
| pubmed-article:12086888 | pubmed:meshHeading | pubmed-meshheading:12086888... | lld:pubmed |
