Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-6-27
pubmed:abstractText
We have developed a mouse model for ovarian carcinoma by using an avian retroviral gene delivery technique for the introduction of multiple genes into somatic ovarian cells of adult mice. Ovarian cells from transgenic mice engineered to express the gene encoding the avian receptor TVA were efficiently infected in vitro with multiple vectors carrying coding sequences for oncogenes and marker genes. When target cells were derived from TVA transgenic mice deficient for p53, the addition of any two of the oncogenes c-myc, K-ras, and Akt were sufficient to induce ovarian tumor formation when infected cells were injected at subcutaneous, intraperitoneal, or ovarian sites. We demonstrated that the ovarian surface epithelium is the precursor tissue for these ovarian carcinomas, and that introduction of oncogenes causes phenotypic changes in the ovarian surface epithelial cells. The induced ovarian tumors in mice resembled human ovarian carcinomas in their rapid progression and intraperitoneal metastatic spread.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10053122, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10077637, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10078924, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10380923, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10409442, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10498877, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10545015, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10675491, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10735013, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10748293, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10753190, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10792785, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10802656, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10822383, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-10883018, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-11207821, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-11294827, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-11323675, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-11323676, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-11485901, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-12086881, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-1409633, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-2227545, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-3041020, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-6263459, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-6933460, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-7532601, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-7657393, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-7922305, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-7972042, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8137211, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8319218, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8383211, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8384077, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8402880, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8634990, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-8643506, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9118042, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9337069, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9448312, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9633840, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9721238, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9721239, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9820870, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9851974, http://linkedlifedata.com/resource/pubmed/commentcorrection/12086888-9916799
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase, http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/Tva receptor
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1535-6108
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-62
pubmed:dateRevised
2011-6-15
pubmed:meshHeading
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