| pubmed-article:12086481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12086481 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:12086481 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:12086481 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12086481 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:12086481 | pubmed:dateCreated | 2002-6-27 | lld:pubmed |
| pubmed-article:12086481 | pubmed:abstractText | A series of diphenyl-substituted heterocycles were synthesized and evaluated by electrophysiological techniques as openers of the cloned mammalian large-conductance, Ca(2+)-activated potassium (maxi-K) channel. The series was designed from deannulation of known benzimidazolone maxi-K opener NS-004 (2) thereby providing an effective template for obtaining structure-activity-related information. The triazolone ring system was the most studied wherein 4,5-diphenyltriazol-3-one 6d (maxi-K = 158%) was identified as the optimal maxi-K channel opener. | lld:pubmed |
| pubmed-article:12086481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12086481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086481 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12086481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12086481 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12086481 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:HugWW | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:LiYiY | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:StarrettJohn... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:GribkoffValen... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:MartinScott... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:BoissardChris... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:MeanwellNicho... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:DworetzkyStev... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:RomineJeffrey... | lld:pubmed |
| pubmed-article:12086481 | pubmed:author | pubmed-author:NataleJoanneJ | lld:pubmed |
| pubmed-article:12086481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12086481 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:12086481 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:12086481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12086481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12086481 | pubmed:pagination | 2942-52 | lld:pubmed |
| pubmed-article:12086481 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:meshHeading | pubmed-meshheading:12086481... | lld:pubmed |
| pubmed-article:12086481 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12086481 | pubmed:articleTitle | 4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels. | lld:pubmed |
| pubmed-article:12086481 | pubmed:affiliation | Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. rominej@bms.com | lld:pubmed |
| pubmed-article:12086481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12086481 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12086481 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086481 | lld:pubmed |
