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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2002-6-27
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pubmed:abstractText |
A series of diphenyl-substituted heterocycles were synthesized and evaluated by electrophysiological techniques as openers of the cloned mammalian large-conductance, Ca(2+)-activated potassium (maxi-K) channel. The series was designed from deannulation of known benzimidazolone maxi-K opener NS-004 (2) thereby providing an effective template for obtaining structure-activity-related information. The triazolone ring system was the most studied wherein 4,5-diphenyltriazol-3-one 6d (maxi-K = 158%) was identified as the optimal maxi-K channel opener.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2942-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12086481-Animals,
pubmed-meshheading:12086481-Crystallography, X-Ray,
pubmed-meshheading:12086481-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:12086481-Models, Molecular,
pubmed-meshheading:12086481-Molecular Conformation,
pubmed-meshheading:12086481-Oocytes,
pubmed-meshheading:12086481-Patch-Clamp Techniques,
pubmed-meshheading:12086481-Potassium Channels, Calcium-Activated,
pubmed-meshheading:12086481-Structure-Activity Relationship,
pubmed-meshheading:12086481-Triazoles,
pubmed-meshheading:12086481-Xenopus laevis
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pubmed:year |
2002
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pubmed:articleTitle |
4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. rominej@bms.com
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pubmed:publicationType |
Journal Article,
In Vitro
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