Source:http://linkedlifedata.com/resource/pubmed/id/12086151
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2002-6-27
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| pubmed:abstractText |
CD4+ HLA-DR+ T cells are known to be increasing in broncho-alveolar lavage fluid (BALF) from patients with sarcoidosis, and related to disease activity. Although there are several reports that the number of gammadelta T cells in peripheral blood from patients with sarcoidosis are increasing, contradictory assertions can be seen about the number of gammadelta T cells in BALF, and the clinical significance on the presence of gammadelta T cells in disease site of patients with diffuse lung disease including sarcoidosis. The absolute number of gammadelta T cells and CD4+ HLA-DR+ T cells in BALF were determined by flow cytometry in 107 patients with diffuse lung diseases; 56 with sarcoidosis, 36 with collagen vascular diseases with lung involvement and 15 with idiopathic pulmonary fibrosis. We also measured the number of the transferrin receptor-positive macrophages in BALF. The correlation between gammadelta T cells and activated (maybe antigen-specific) T cells and macrophages were evaluated. Sarcoidosis patients were also evaluated from the data of the number of gammadelta T cells in peripheral blood by flow cytometry and clinical backgrounds. A significant correlation between the numbers of these two cell types was detected in each of the three patient groups. The percentage of peripheral gammadelta T cells was markedly increased in 7 sarcoidosis patients, each of whom also showed affected organs other than lung, however, 5 individuals did not show an increased number of gammadelta T cells in BALF. The number of gammadelta T cells in BALF did not correlate with the number of transferrin receptor-positive macrophages in all three patient groups. These results suggest that the increased number of gammadelta T cells in diffuse lung diseases likely plays a role in immunosurveillance and contributes to the activation of antigen-specific alphabeta T cell.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0040-8727
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
196
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
231-40
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12086151-Adult,
pubmed-meshheading:12086151-Arthritis, Rheumatoid,
pubmed-meshheading:12086151-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:12086151-CD4 Lymphocyte Count,
pubmed-meshheading:12086151-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12086151-Collagen Diseases,
pubmed-meshheading:12086151-Dermatomyositis,
pubmed-meshheading:12086151-Female,
pubmed-meshheading:12086151-HLA-DR Antigens,
pubmed-meshheading:12086151-Humans,
pubmed-meshheading:12086151-Lung Diseases,
pubmed-meshheading:12086151-Lupus Erythematosus, Systemic,
pubmed-meshheading:12086151-Lymphocyte Count,
pubmed-meshheading:12086151-Male,
pubmed-meshheading:12086151-Middle Aged,
pubmed-meshheading:12086151-Mixed Connective Tissue Disease,
pubmed-meshheading:12086151-Polyarteritis Nodosa,
pubmed-meshheading:12086151-Polymyositis,
pubmed-meshheading:12086151-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12086151-Sarcoidosis,
pubmed-meshheading:12086151-Scleroderma, Systemic,
pubmed-meshheading:12086151-T-Lymphocytes
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| pubmed:year |
2002
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| pubmed:articleTitle |
Correlation between the numbers of gammadelta T cells and CD4+ HLA-DR+ T cells in broncho-alveolar lavage fluid from patients with diffuse lung disease.
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| pubmed:affiliation |
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan. eiichi@med.niigata-u.ac.jp
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| pubmed:publicationType |
Journal Article
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