Linked Life Data

12084508

Source:http://linkedlifedata.com/resource/pubmed/id/12084508

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-6-26
pubmed:abstractText
A very low soluble pectin-derivative (pectinic acid, degree of methoxylation 4%) was found to be well suited as an excipient for pelletisation by extrusion/spheronisation. Formulations containing pectinic acid and lactose in the following ratios were evaluated: 99/1, 80/20, 50/50 and 20/80. The capacity as an extrusion aid was found to be high; even formulations containing only 20% pectinic acid resulted in nearly spherical pellets. All pectinic acid pellets were mechanically stable, had an aspect ratio of approximately 1.15-1.20 and released 30-60% of a low solubility model drug within 15 min both in simulated gastric acid (0.1M HCl) and intestinal fluid (phosphate buffer pH 6.8).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0939-6411
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Pectinic acid, a novel excipient for production of pellets by extrusion/spheronisation: preliminary studies.
pubmed:affiliation
Department of Pharmaceutics, School of Pharmacy, University of Oslo, PO Box 1068, Blindern, N-0316 Oslo, Norway. ingunn.tho@farmasi.uio.no
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't