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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-6-25
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pubmed:abstractText |
Osteopontin (OPN) is a macrophage adhesive and cell survival factor that is up-regulated in tubules in tubulointerstitial disease. We have previously reported that rats with cyclosporine (CsA) nephropathy have increased tubular osteopontin that correlates with the infiltration of macrophages and interstitial fibrosis. This study tested the hypothesis that the absence of OPN would ameliorate CsA nephropathy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Osteopontin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spp1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0085-2538
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pubmed:author |
pubmed-author:AlpersCharles ECE,
pubmed-author:CouserWilliam GWG,
pubmed-author:DantasMarcioM,
pubmed-author:GiachelliCecilia MCM,
pubmed-author:HughesJeremyJ,
pubmed-author:JohnsonRichard JRJ,
pubmed-author:LanHui YHY,
pubmed-author:MazzaliMarildaM,
pubmed-author:PichlerRaimund HRH,
pubmed-author:ShanklandStuart JSJ,
pubmed-author:SteitzSusanS,
pubmed-author:WanT TTT
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
78-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12081566-Animals,
pubmed-meshheading:12081566-Apoptosis,
pubmed-meshheading:12081566-Cell Division,
pubmed-meshheading:12081566-Cyclosporine,
pubmed-meshheading:12081566-Fibrosis,
pubmed-meshheading:12081566-Immunosuppressive Agents,
pubmed-meshheading:12081566-Kidney,
pubmed-meshheading:12081566-Macrophages,
pubmed-meshheading:12081566-Mice,
pubmed-meshheading:12081566-Mice, Knockout,
pubmed-meshheading:12081566-Osteopontin,
pubmed-meshheading:12081566-RNA, Messenger,
pubmed-meshheading:12081566-Sialoglycoproteins,
pubmed-meshheading:12081566-Transforming Growth Factor beta,
pubmed-meshheading:12081566-Transforming Growth Factor beta1
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of cyclosporine in osteopontin null mice.
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pubmed:affiliation |
Division of Nephrology, Department of Pathology, University of Washington, Seattle, Washington, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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