Source:http://linkedlifedata.com/resource/pubmed/id/12081097
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2002-6-25
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| pubmed:abstractText |
Flaviviridae-hepatitis C virus (HCV) and GB virus C/hepatitis G virus (GBV-C/HGV)--and human immunodeficiency virus (HIV) frequently show similar modes of transmission. HCV and GBV-C/HGV infection was assessed in 134 consecutive patients with evidence of HIV infection, living in Campania, Italy. Data obtained from this cohort were compared with those obtained from 252 age- and sex-matched HCV infected patients without evidence of HIV infection (HCV control group). Following enzymatic immunoassays, samples were tested for the presence of HCV-RNA by RT-PCR. The HCV-RNA positive sera were genotyped by LiPA procedure. The prevalence of HCV infection in HIV patients was 19.40% and the largest group of HIV-HCV co-infected patients (84.62%) was represented by intravenous drug users (IVDU). The distribution of HCV genotypes in HIV-HCV patients was different, compared to that observed in HCV control group. HCV genotypes la (50%) and 3a (23.08%) were more frequently detected in HIV HCV patients, compared to HCV control group (5.16 and 5.56% for la and 3a, respectively). Conversely, HCV genotypes lb (55.70%) and 2a/2c (30.26%) were more represented in HCV control group, compared to HIV-HCV patients (15.38 and 0% for lb and 2a/2c, respectively). GBV-C/HGV seroprevalence was 41.04% in HIV patients and 6.54% in healthy control individuals. Differently from HCV, GBV-C/HGV infection did not correlate to a preferential risk behaviour in the HIV cohort. Comparative analysis of HCV and GBV-C/HGV infection indicates that the use of injecting drugs might play a key role in the epidemiology of HCV and, in particular, of la and 3a HCV genotypes, in HIV patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0393-2990
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| pubmed:author |
pubmed-author:BonadiesGG,
pubmed-author:BonavoltaRR,
pubmed-author:BorgiaGG,
pubmed-author:D'OnofrioMM,
pubmed-author:FormisanoPP,
pubmed-author:IuraAA,
pubmed-author:LaccettiPP,
pubmed-author:LaccettiRR,
pubmed-author:LiuzzoAA,
pubmed-author:PietronigroM TMT,
pubmed-author:PortellaGG,
pubmed-author:RendinaDD,
pubmed-author:VigoritaEE
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| pubmed:issnType |
Print
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
801-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12081097-Adult,
pubmed-meshheading:12081097-Case-Control Studies,
pubmed-meshheading:12081097-Chi-Square Distribution,
pubmed-meshheading:12081097-Female,
pubmed-meshheading:12081097-Flaviviridae Infections,
pubmed-meshheading:12081097-GB virus C,
pubmed-meshheading:12081097-Genotype,
pubmed-meshheading:12081097-HIV Infections,
pubmed-meshheading:12081097-Hepacivirus,
pubmed-meshheading:12081097-Hepatitis, Viral, Human,
pubmed-meshheading:12081097-Hepatitis C,
pubmed-meshheading:12081097-Humans,
pubmed-meshheading:12081097-Immunoenzyme Techniques,
pubmed-meshheading:12081097-Italy,
pubmed-meshheading:12081097-Male,
pubmed-meshheading:12081097-Prevalence,
pubmed-meshheading:12081097-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12081097-Risk Factors,
pubmed-meshheading:12081097-Substance Abuse, Intravenous
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| pubmed:year |
2001
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| pubmed:articleTitle |
HCV and GBV-c/HGV infection in HIV positive patients in southern Italy.
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| pubmed:affiliation |
Dipartimento Assistenziale di Patologia Clinica, Facoltà di Medicina e Chirurgia Università di Napoli Federico II, Italy.
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| pubmed:publicationType |
Journal Article
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