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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2002-6-24
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|
pubmed:abstractText |
The multi-faceted components of the metabolic syndrome now include markers of inflammation and endothelial activation. Despite this growing body of epidemiological data, standard statistical methods fail to evaluate the nature of these associations adequately. In this pilot study, we hypothesize that obesity may lead to endothelial activation which is in part mediated by dyslipidaemia and proinflammatory cytokines. These factors interact to give rise to hyperinsulinaemia, hypertension and an anti-fibrinolytic state. To test this hypothesis, we used confirmatory factor analysis and structural equation modelling to fit these data to a model designed on theoretical grounds.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0307-0565
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
994-1008
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12080455-Adult,
pubmed-meshheading:12080455-Aged,
pubmed-meshheading:12080455-Aging,
pubmed-meshheading:12080455-Blood Pressure,
pubmed-meshheading:12080455-Body Composition,
pubmed-meshheading:12080455-Body Constitution,
pubmed-meshheading:12080455-Body Mass Index,
pubmed-meshheading:12080455-Cholesterol, HDL,
pubmed-meshheading:12080455-Cholesterol, LDL,
pubmed-meshheading:12080455-Cytokines,
pubmed-meshheading:12080455-Endothelium, Vascular,
pubmed-meshheading:12080455-Female,
pubmed-meshheading:12080455-Fibrinolysis,
pubmed-meshheading:12080455-Humans,
pubmed-meshheading:12080455-Hyperinsulinism,
pubmed-meshheading:12080455-Hyperlipidemias,
pubmed-meshheading:12080455-Inflammation,
pubmed-meshheading:12080455-Interleukin-6,
pubmed-meshheading:12080455-Male,
pubmed-meshheading:12080455-Metabolic Syndrome X,
pubmed-meshheading:12080455-Middle Aged,
pubmed-meshheading:12080455-Obesity,
pubmed-meshheading:12080455-Sex Characteristics,
pubmed-meshheading:12080455-Smoking,
pubmed-meshheading:12080455-Triglycerides,
pubmed-meshheading:12080455-Tumor Necrosis Factor-alpha
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|
pubmed:year |
2002
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|
pubmed:articleTitle |
The central roles of obesity-associated dyslipidaemia, endothelial activation and cytokines in the Metabolic Syndrome--an analysis by structural equation modelling.
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|
pubmed:affiliation |
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, NT, Hong Kong, China. jchan@cuhk.edu.hk
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
