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rdf:type |
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lifeskim:mentions |
umls-concept:C0017725,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0205409,
umls-concept:C0206131,
umls-concept:C0243192,
umls-concept:C0299583,
umls-concept:C0529579,
umls-concept:C0598783,
umls-concept:C1280500
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pubmed:issue |
7
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pubmed:dateCreated |
2002-6-24
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pubmed:abstractText |
Leptin, a hormone produced in adipocytes, is a key signal in the regulation of food intake and energy expenditure. Beta-adrenergic agonists have been shown to inhibit leptin gene expression and leptin secretion. The mechanisms underlying the inhibitory effects of beta-adrenergic agonists have not been established. In this study, we examined the effects of Trecadrine, a novel beta3-adrenergic agonist, on basal and insulin-stimulated leptin secretion in isolated rat adipocytes. Because insulin-stimulated glucose metabolism is an important regulator of leptin expression and secretion by the adipocytes, the effects of Trecadrine on indices of adipocyte metabolism were also examined.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Benzyl Alcohols,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/trecadrine
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0307-0565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
912-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12080443-Adipocytes,
pubmed-meshheading:12080443-Adrenergic beta-Agonists,
pubmed-meshheading:12080443-Animals,
pubmed-meshheading:12080443-Benzyl Alcohols,
pubmed-meshheading:12080443-Cells, Cultured,
pubmed-meshheading:12080443-Gene Expression,
pubmed-meshheading:12080443-Glucose,
pubmed-meshheading:12080443-Lactic Acid,
pubmed-meshheading:12080443-Leptin,
pubmed-meshheading:12080443-Lipid Metabolism,
pubmed-meshheading:12080443-Lipolysis,
pubmed-meshheading:12080443-Male,
pubmed-meshheading:12080443-Oxidation-Reduction,
pubmed-meshheading:12080443-RNA, Messenger,
pubmed-meshheading:12080443-Rats,
pubmed-meshheading:12080443-Rats, Sprague-Dawley,
pubmed-meshheading:12080443-Receptors, Adrenergic, beta-3,
pubmed-meshheading:12080443-Triglycerides
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of Trecadrine, a beta3-adrenergic agonist, on leptin secretion, glucose and lipid metabolism in isolated rat adipocytes.
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pubmed:affiliation |
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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