Linked Life Data

12077730

Source:http://linkedlifedata.com/resource/pubmed/id/12077730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-6-21
pubmed:abstractText
Lipid responses to a dietary intervention are highly variable between individuals. Part of this variation may be accounted for by individual differences in lipid-regulating genes that interact with diet to induce changes in lipoprotein metabolism. This study determined whether apolipoprotein E (APOE) genotype affects lipid responses to a low-fat, low-cholesterol diet in obese, postmenopausal women. Body weight and lipoprotein lipid responses to a 10-week, dietary intervention (American Heart Association [AHA] Step I) were compared in 61 women with the APOE 2/3 and APOE 3/3 genotype (APOE4-) and 18 women with the APOE 3/4 genotype (APOE4+) of a similar age, body composition, and maximal aerobic capacity. Body weight decreased by 2% in both groups, but changes in body weight correlated only with changes in low-density lipoprotein-cholesterol (LDL-C) (r =.27, P <.05). The dietary intervention decreased total cholesterol and LDL-C to a similar degree in both genotype groups. However, APOE4- women decreased high-density lipoprotein-cholesterol (HDL-C) by 17% +/- 11% and increased triglycerides by 20% +/- 41% in response to the diet, while APOE4+ women had a smaller decrease in HDL-C (-8% +/- 12%) and no change in plasma triglyceride. These group differences were significant for HDL-C (P <.01) and approached significance for triglycerides (P =.08). Moreover, APOE4- women decreased HDL(2)-C by 32% +/- 45%, while APOE4+ women increased HDL(2)-C by 12% +/- 62% (P <.01 between groups). It may be prudent to genotype older women before initiating low-fat diet therapy, as those with the APOE4 allele benefit the most, while the lipid profile could worsen in women without the APOE4 allele.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0026-0495
pubmed:author
pubmed:copyrightInfo
Copyright 2002, Elsevier Science (USA). All rights reserved.
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
853-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12077730-Aged, pubmed-meshheading:12077730-Alleles, pubmed-meshheading:12077730-Apolipoprotein E4, pubmed-meshheading:12077730-Apolipoproteins E, pubmed-meshheading:12077730-Body Composition, pubmed-meshheading:12077730-Body Weight, pubmed-meshheading:12077730-Cholesterol, pubmed-meshheading:12077730-Cholesterol, HDL, pubmed-meshheading:12077730-Cholesterol, LDL, pubmed-meshheading:12077730-Diet, pubmed-meshheading:12077730-Dietary Fats, pubmed-meshheading:12077730-Energy Intake, pubmed-meshheading:12077730-European Continental Ancestry Group, pubmed-meshheading:12077730-Female, pubmed-meshheading:12077730-Gene Frequency, pubmed-meshheading:12077730-Genotype, pubmed-meshheading:12077730-Humans, pubmed-meshheading:12077730-Middle Aged, pubmed-meshheading:12077730-Obesity, pubmed-meshheading:12077730-Postmenopause, pubmed-meshheading:12077730-Regression Analysis
pubmed:year
2002
pubmed:articleTitle
Effects of apolipoprotein E genotype on dietary-induced changes in high-density lipoprotein cholesterol in obese postmenopausal women.
pubmed:affiliation
Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, and the Geriatric Research, Education and Clinical Center (GRECC), Baltimore VA Medical Center, Baltimore, MD, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.