| pubmed-article:12070661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0752125 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0665827 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12070661 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12070661 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12070661 | pubmed:dateCreated | 2002-6-18 | lld:pubmed |
| pubmed-article:12070661 | pubmed:abstractText | Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder primarily affecting the cerebellum, brain stem and retina. The disease is caused by an expanded polyglutamine tract in the protein ataxin-7. In this study we analyzed the expression pattern of ataxin-7 in CNS and non-CNS tissue from three SCA7 patients and age-matched controls. SCA7 is a rare autosomal dominant disorder, limiting the number of patients available for analysis. We therefore compiled data on ataxin-7 expression from all SCA7 patients (n=5) and controls (n=7) published to date, and compared with the results obtained in this study. Expression of ataxin-7 was found in neurons throughout the CNS and was highly abundant in Purkinje cells of the cerebellum, in regions of the hippocampus and in cerebral cortex. Ataxin-7 expression was not restricted to regions of pathology, and there were no apparent regional differences in ataxin-7 expression patterns between patients and controls. The subcellular distribution of ataxin-7 was primarily nuclear in all brain regions studied. In cerebellar Purkinje cells, however, differences in subcellular distribution of ataxin-7 were observed between patients and controls of different ages. Here we provide an increased understanding of the distribution of ataxin-7, and the possible implication of subcellular localization of this protein on disease pathology is discussed. | lld:pubmed |
| pubmed-article:12070661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12070661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12070661 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12070661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12070661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12070661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12070661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12070661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12070661 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12070661 | pubmed:issn | 0001-6322 | lld:pubmed |
| pubmed-article:12070661 | pubmed:author | pubmed-author:BrännströmTho... | lld:pubmed |
| pubmed-article:12070661 | pubmed:author | pubmed-author:ForsgrenLarsL | lld:pubmed |
| pubmed-article:12070661 | pubmed:author | pubmed-author:JonassonJenni... | lld:pubmed |
| pubmed-article:12070661 | pubmed:author | pubmed-author:HartPatriciaP | lld:pubmed |
| pubmed-article:12070661 | pubmed:author | pubmed-author:HolmbergMonic... | lld:pubmed |
| pubmed-article:12070661 | pubmed:author | pubmed-author:StrömAnna-Len... | lld:pubmed |
| pubmed-article:12070661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12070661 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:12070661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12070661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12070661 | pubmed:pagination | 29-37 | lld:pubmed |
| pubmed-article:12070661 | pubmed:dateRevised | 2007-11-9 | lld:pubmed |
| pubmed-article:12070661 | pubmed:meshHeading | pubmed-meshheading:12070661... | lld:pubmed |
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| pubmed-article:12070661 | pubmed:meshHeading | pubmed-meshheading:12070661... | lld:pubmed |
| pubmed-article:12070661 | pubmed:meshHeading | pubmed-meshheading:12070661... | lld:pubmed |
| pubmed-article:12070661 | pubmed:meshHeading | pubmed-meshheading:12070661... | lld:pubmed |
| pubmed-article:12070661 | pubmed:meshHeading | pubmed-meshheading:12070661... | lld:pubmed |
| pubmed-article:12070661 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12070661 | pubmed:articleTitle | Expression of ataxin-7 in CNS and non-CNS tissue of normal and SCA7 individuals. | lld:pubmed |
| pubmed-article:12070661 | pubmed:affiliation | Department of Molecular Biology, Umeå University, Sweden. | lld:pubmed |
| pubmed-article:12070661 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12070661 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6314 | entrezgene:pubmed | pubmed-article:12070661 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12070661 | lld:entrezgene |
