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rdf:type |
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lifeskim:mentions |
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0254610,
umls-concept:C0334094,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2916969
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pubmed:issue |
12
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pubmed:dateCreated |
2002-6-18
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pubmed:abstractText |
The generation and efficient maintenance of antigen-specific memory T cells is essential for long-lasting immunological protection. In this study, we examined the role of interleukin (IL)-15 in the generation and maintenance of virus-specific memory CD8 T cells using mice deficient in either IL-15 or the IL-15 receptor alpha chain. Both cytokine- and receptor-deficient mice made potent primary CD8 T cell responses to infection with lymphocytic choriomeningitis virus (LCMV), effectively cleared the virus and generated a pool of antigen-specific memory CD8 T cells that were phenotypically and functionally similar to memory CD8 T cells present in IL-15(+/+) mice. However, longitudinal analysis revealed a slow attrition of virus-specific memory CD8 T cells in the absence of IL-15 signals. This loss of CD8 T cells was due to a severe defect in the proliferative renewal of antigen-specific memory CD8 T cells in IL-15(-/-) mice. Taken together, these results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10322146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10475676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10558996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10558997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10704459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10748241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10784451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10881174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-10925249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11062503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11208862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11228420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11264538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11323695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11323696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11344265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11698427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11698438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-11877489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-12070294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-6332167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-7516039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-8600537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-8658169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-8782700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-8810254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9197272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9491999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9501216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9620680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9846488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9933110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12070282-9933111
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1541-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12070282-Animals,
pubmed-meshheading:12070282-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12070282-Cell Division,
pubmed-meshheading:12070282-Female,
pubmed-meshheading:12070282-Homeostasis,
pubmed-meshheading:12070282-Immunologic Memory,
pubmed-meshheading:12070282-Interleukin-15,
pubmed-meshheading:12070282-Mice,
pubmed-meshheading:12070282-Mice, Inbred C57BL,
pubmed-meshheading:12070282-Mice, Knockout,
pubmed-meshheading:12070282-Viruses
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pubmed:year |
2002
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pubmed:articleTitle |
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.
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pubmed:affiliation |
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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