Linked Life Data

12069158

Source:http://linkedlifedata.com/resource/pubmed/id/12069158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-6-18
pubmed:abstractText
Synthetic polymers and gels capable of molecular recognition are very useful in designing novel intelligent biomaterials. In this article we review the recent progress in both theoretical and experimental studies toward making heteropolymers and gels with biomimetic properties, specifically in relation to protein recognition. Knowledge obtained from protein-folding studies sheds much light on our understanding of the heteropolymer behavior. Consequently, it is possible to design synthetic heteropolymers with specific structure that can fold into unique conformations, form receptor-like cavities and recognize specific target molecules. Recent studies towards simplifying the requirement for the heteropolymer structures and the polymerization procedures are reviewed. Intelligent polymer gels can be designed with new and interesting characteristics of molecular imprinting. The results are encouraging for further investigation and design of synthetic gels with programmable collapsed structure might be achieved.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0724-8741
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
578-87
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Polymers and gels as molecular recognition agents.
pubmed:affiliation
Department of Biochemical Engineering, Purdue University, West Lafayette, Indiana 47907-1283, USA. peppas@ecn.purdue.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review