| pubmed-article:12068290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C0017132 | lld:lifeskim |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12068290 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:12068290 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12068290 | pubmed:dateCreated | 2002-7-1 | lld:pubmed |
| pubmed-article:12068290 | pubmed:abstractText | Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. Wild-type mice fed a high-fat diet exhibited both hypersecretion of GIP and extreme visceral and subcutaneous fat deposition with insulin resistance. In contrast, mice lacking the GIP receptor (Gipr(-/-)) fed a high-fat diet were clearly protected from both the obesity and the insulin resistance. Moreover, double-homozygous mice (Gipr(-/-), Lep(ob)/Lep(ob)) generated by crossbreeding Gipr(-/-) and obese ob/ob (Lep(ob)/Lep(ob)) mice gained less weight and had lower adiposity than Lep(ob)/Lep(ob) mice. The Gipr(-/-) mice had a lower respiratory quotient and used fat as the preferred energy substrate, and were thus resistant to obesity. Therefore, GIP directly links overnutrition to obesity and it is a potential target for anti-obesity drugs. | lld:pubmed |
| pubmed-article:12068290 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12068290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12068290 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12068290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12068290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12068290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12068290 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12068290 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:ToyokuniShiny... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:HolstJens... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:FujimotoShimp... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:YamadaYuichir... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:SeinoYutakaY | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:HiaiHiroshiH | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:TsubamotoYosh... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:FushikiTohruT | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:BanNobuhiroN | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:MiyawakiKazum... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:IharaYuY | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:TsudaKinsukeK | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:MizunoyaWatar... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:OkuAkiraA | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:TsukiyamaKats... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:ZhouHeyingH | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:MakinoMitsuhi... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:TashitaAkiraA | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:KobaraYukariY | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:JinnouchiTaka... | lld:pubmed |
| pubmed-article:12068290 | pubmed:author | pubmed-author:JomoriTakahit... | lld:pubmed |
| pubmed-article:12068290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12068290 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:12068290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12068290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12068290 | pubmed:pagination | 738-42 | lld:pubmed |
| pubmed-article:12068290 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12068290 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12068290 | pubmed:articleTitle | Inhibition of gastric inhibitory polypeptide signaling prevents obesity. | lld:pubmed |
| pubmed-article:12068290 | pubmed:affiliation | Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan. | lld:pubmed |
| pubmed-article:12068290 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12068290 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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