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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-7-1
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pubmed:abstractText |
Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. Wild-type mice fed a high-fat diet exhibited both hypersecretion of GIP and extreme visceral and subcutaneous fat deposition with insulin resistance. In contrast, mice lacking the GIP receptor (Gipr(-/-)) fed a high-fat diet were clearly protected from both the obesity and the insulin resistance. Moreover, double-homozygous mice (Gipr(-/-), Lep(ob)/Lep(ob)) generated by crossbreeding Gipr(-/-) and obese ob/ob (Lep(ob)/Lep(ob)) mice gained less weight and had lower adiposity than Lep(ob)/Lep(ob) mice. The Gipr(-/-) mice had a lower respiratory quotient and used fat as the preferred energy substrate, and were thus resistant to obesity. Therefore, GIP directly links overnutrition to obesity and it is a potential target for anti-obesity drugs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:BanNobuhiroN,
pubmed-author:FujimotoShimpeiS,
pubmed-author:FushikiTohruT,
pubmed-author:HiaiHiroshiH,
pubmed-author:HolstJens JuulJJ,
pubmed-author:IharaYuY,
pubmed-author:JinnouchiTakayoshiT,
pubmed-author:JomoriTakahitoT,
pubmed-author:KobaraYukariY,
pubmed-author:MakinoMitsuhiroM,
pubmed-author:MiyawakiKazumasaK,
pubmed-author:MizunoyaWataruW,
pubmed-author:OkuAkiraA,
pubmed-author:SeinoYutakaY,
pubmed-author:TashitaAkiraA,
pubmed-author:ToyokuniShinyaS,
pubmed-author:TsubamotoYoshiharuY,
pubmed-author:TsudaKinsukeK,
pubmed-author:TsukiyamaKatsushiK,
pubmed-author:YamadaYuichiroY,
pubmed-author:ZhouHeyingH
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
738-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12068290-Adipose Tissue,
pubmed-meshheading:12068290-Animals,
pubmed-meshheading:12068290-Body Weight,
pubmed-meshheading:12068290-Crosses, Genetic,
pubmed-meshheading:12068290-Dietary Fats,
pubmed-meshheading:12068290-Gastric Inhibitory Polypeptide,
pubmed-meshheading:12068290-Mice,
pubmed-meshheading:12068290-Mice, Knockout,
pubmed-meshheading:12068290-Obesity,
pubmed-meshheading:12068290-Receptors, Gastrointestinal Hormone,
pubmed-meshheading:12068290-Signal Transduction
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pubmed:year |
2002
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pubmed:articleTitle |
Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
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pubmed:affiliation |
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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