Source:http://linkedlifedata.com/resource/pubmed/id/12067843
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-6-17
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| pubmed:abstractText |
We evaluated lipid metabolism during 90 min of moderate-intensity (50% VO(2) peak) cycle ergometer exercise in five men and five women who were matched on adiposity (24 +/- 2 and 25 +/- 1% body fat, respectively) and aerobic fitness (VO(2) peak: 49 +/- 2 and 47 +/- 1 ml x kg fat-free mass(-1) x min(-1), respectively). Substrate oxidation and lipid kinetics were measured by using indirect calorimetry and [(13)C]palmitate and [(2)H(5)]glycerol tracer infusion. The total increase in glycerol and free fatty acid (FFA) rate of appearance (R(a)) in plasma during exercise (area under the curve above baseline) was approximately 65% greater in women than in men (glycerol R(a): 317 +/- 40 and 195 +/- 33 micromol/kg, respectively; FFA R(a): 652 +/- 46 and 453 +/- 70 micromol/kg, respectively; both P < 0.05). Total fatty acid oxidation was similar in men and women, but the relative contribution of plasma FFA to total fatty acid oxidation was higher in women (76 +/- 5%) than in men (46 +/- 5%; P < 0.05). We conclude that lipolysis of adipose tissue triglycerides during moderate-intensity exercise is greater in women than in men, who are matched on adiposity and fitness. The increase in plasma fatty acid availability leads to a greater rate of plasma FFA tissue uptake and oxidation in women than in men. However, total fat oxidation is the same in both groups because of a reciprocal decrease in the oxidation rate of fatty acids derived from nonplasma sources, presumably intramuscular and possibly plasma triglycerides, in women.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerol,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitic Acid
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0193-1849
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
283
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
E58-65
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12067843-Adult,
pubmed-meshheading:12067843-Body Composition,
pubmed-meshheading:12067843-Calorimetry, Indirect,
pubmed-meshheading:12067843-Epinephrine,
pubmed-meshheading:12067843-Exercise Test,
pubmed-meshheading:12067843-Fatty Acids, Nonesterified,
pubmed-meshheading:12067843-Female,
pubmed-meshheading:12067843-Glycerol,
pubmed-meshheading:12067843-Humans,
pubmed-meshheading:12067843-Infusions, Intravenous,
pubmed-meshheading:12067843-Insulin,
pubmed-meshheading:12067843-Lipid Metabolism,
pubmed-meshheading:12067843-Lipids,
pubmed-meshheading:12067843-Male,
pubmed-meshheading:12067843-Norepinephrine,
pubmed-meshheading:12067843-Oxidation-Reduction,
pubmed-meshheading:12067843-Oxygen Consumption,
pubmed-meshheading:12067843-Palmitic Acid,
pubmed-meshheading:12067843-Physical Exertion,
pubmed-meshheading:12067843-Physical Fitness,
pubmed-meshheading:12067843-Sex Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects.
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| pubmed:affiliation |
Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
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