12067555

Source:http://linkedlifedata.com/resource/pubmed/id/12067555

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010573, umls-concept:C0243076, umls-concept:C0597357
pubmed:issue	13
pubmed:dateCreated	2002-6-17
pubmed:abstractText	A series of novel 4,4-disubstituted cyclohexylamines as NK(1) receptor antagonists is described: modifications to the amine moiety retain NK(1) receptor binding affinity whilst disrupting I(Kr) affinity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Amines, http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans, http://linkedlifedata.com/resource/pubmed/chemical/Cation Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexylamines, http://linkedlifedata.com/resource/pubmed/chemical/Ether-A-Go-Go Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/KCNH6 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/L 706000, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0960-894X
pubmed:author	pubmed-author:CarlsonEmma JEJ, pubmed-author:CastroJose LJL, pubmed-author:ChicchiGary GGG, pubmed-author:CooperLaura CLC, pubmed-author:Di SalvoJerryJ, pubmed-author:DinnellKevinK, pubmed-author:ElliottJason MJM, pubmed-author:HollingworthGregory JGJ, pubmed-author:KurtzMarc MMM, pubmed-author:RidgillMark PMP, pubmed-author:RycroftWayneW, pubmed-author:SwainChristopher JCJ, pubmed-author:TsaoKwei-LanKL
pubmed:issnType	Print
pubmed:day	8
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1759-62
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:12067555-Amines, pubmed-meshheading:12067555-Animals, pubmed-meshheading:12067555-Benzopyrans, pubmed-meshheading:12067555-Binding Sites, pubmed-meshheading:12067555-CHO Cells, pubmed-meshheading:12067555-Cation Transport Proteins, pubmed-meshheading:12067555-Clone Cells, pubmed-meshheading:12067555-Cricetinae, pubmed-meshheading:12067555-Cyclohexylamines, pubmed-meshheading:12067555-Ether-A-Go-Go Potassium Channels, pubmed-meshheading:12067555-Gerbillinae, pubmed-meshheading:12067555-Inhibitory Concentration 50, pubmed-meshheading:12067555-Models, Molecular, pubmed-meshheading:12067555-Molecular Conformation, pubmed-meshheading:12067555-Piperidines, pubmed-meshheading:12067555-Potassium Channels, pubmed-meshheading:12067555-Potassium Channels, Voltage-Gated, pubmed-meshheading:12067555-Radioligand Assay, pubmed-meshheading:12067555-Receptors, Neurokinin-1, pubmed-meshheading:12067555-Structure-Activity Relationship, pubmed-meshheading:12067555-Time Factors
pubmed:year	2002
pubmed:articleTitle	4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II.
pubmed:affiliation	Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. laura_cooper@merck.com
pubmed:publicationType	Journal Article