Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1976-3-15
pubmed:abstractText
C57BL and BALB/c mice were exposed to fresh cigarette smoke for 7-8 minutes per day for varying periods up to 30 weeks before subcutaneous or intratracheal inoculation of viable tumor cells. The growth rates of subcutaneous tumors in the mice exposed to smoke were significantly higher than those of controls and more lung metastases were noted. Enhanced tumor growth rates in the respiratory tracts of smoke-exposed mice were evidenced by the markedly increased death rates in these animals after the intratracheal inoculation of tumor cells. Increased tumor growth rates in mice that inhaled smoke were assoicated with depressed tumor-specific cytotoxic responses in both spleens and regional lymph nodes. Short-term exposure (10 wk) of mice to cigarette smoke resulted in decreased tumor growth rates concomitant with enhanced cytotoxic responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1129-34
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed-meshheading:1206738-Animals, pubmed-meshheading:1206738-Antigen-Antibody Complex, pubmed-meshheading:1206738-Cytotoxicity Tests, Immunologic, pubmed-meshheading:1206738-Female, pubmed-meshheading:1206738-Immunity, Cellular, pubmed-meshheading:1206738-Injections, Subcutaneous, pubmed-meshheading:1206738-Intubation, Intratracheal, pubmed-meshheading:1206738-Lung Neoplasms, pubmed-meshheading:1206738-Lymph Nodes, pubmed-meshheading:1206738-Lymphocytes, pubmed-meshheading:1206738-Male, pubmed-meshheading:1206738-Mice, pubmed-meshheading:1206738-Mice, Inbred BALB C, pubmed-meshheading:1206738-Mice, Inbred C57BL, pubmed-meshheading:1206738-Neoplasm Metastasis, pubmed-meshheading:1206738-Neoplasm Transplantation, pubmed-meshheading:1206738-Neoplasms, Experimental, pubmed-meshheading:1206738-Respiratory Tract Neoplasms, pubmed-meshheading:1206738-Skin Neoplasms, pubmed-meshheading:1206738-Smoking, pubmed-meshheading:1206738-Spleen, pubmed-meshheading:1206738-Time Factors, pubmed-meshheading:1206738-Transplantation, Homologous
pubmed:year
1975
pubmed:articleTitle
Cell-mediated immune responses to transplanted tumors in mice chronically exposed to cigarette smoke.
pubmed:publicationType
Journal Article