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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-6-14
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pubmed:abstractText |
Statins, anti-hypercholesterolemic agents, have previously been reported to induce apoptosis and exert antitumor activity when combined with other antitumor agents. The potential of lovastatin in combination with highly specific COX-2 inhibitor (MF-tricyclic) to induce anti-proliferative activity against tumour cells was evaluated using the combination index (CI) method. Murine colorectal cancer (colon-26, CMT-93), melanoma (B16F10) and human bladder carcinoma cells (T24) were tested. Exposure of colon-26 and CMT-93 cells resulted in synergistic interactions in both cell lines with CI<1 for 20-80% inhibition of cell growth in both cell lines. This synergy was not observed in the B16F10 melanoma and T24 bladder carcinoma cells. MF-tricyclic (40 microg/ml), augmented lovastatin-induced apoptosis up to 2.5-fold in colon-26 cancer cells. Combination of a specific COX-2 inhibitor, MF-tricyclic, may increase antiproliferative effects of lovastatin in colon cancer cells and this effect was due to an augmented apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(3,4-difluorophenyl)-4-(4-(methyls...,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Furans,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lovastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:issn |
1021-335X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
879-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12066226-Adenocarcinoma,
pubmed-meshheading:12066226-Animals,
pubmed-meshheading:12066226-Antineoplastic Agents,
pubmed-meshheading:12066226-Apoptosis,
pubmed-meshheading:12066226-Cell Division,
pubmed-meshheading:12066226-Colorectal Neoplasms,
pubmed-meshheading:12066226-Cyclooxygenase 2,
pubmed-meshheading:12066226-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12066226-Cyclooxygenase Inhibitors,
pubmed-meshheading:12066226-Drug Interactions,
pubmed-meshheading:12066226-Drug Synergism,
pubmed-meshheading:12066226-Drug Therapy, Combination,
pubmed-meshheading:12066226-Furans,
pubmed-meshheading:12066226-Humans,
pubmed-meshheading:12066226-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:12066226-Isoenzymes,
pubmed-meshheading:12066226-Lovastatin,
pubmed-meshheading:12066226-Melanoma,
pubmed-meshheading:12066226-Membrane Proteins,
pubmed-meshheading:12066226-Mice,
pubmed-meshheading:12066226-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12066226-Tetrazolium Salts,
pubmed-meshheading:12066226-Thiazoles,
pubmed-meshheading:12066226-Tumor Cells, Cultured,
pubmed-meshheading:12066226-Urinary Bladder Neoplasms
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pubmed:articleTitle |
Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines.
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pubmed:affiliation |
Department of Immunology, Centre of Biostructure Research, The Medical University of Warsaw, Poland. wfeleszk@ib.amwaw.edu.pl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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