| pubmed-article:12065675 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C1882864 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0013355 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0070651 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:12065675 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12065675 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12065675 | pubmed:dateCreated | 2002-6-14 | lld:pubmed |
| pubmed-article:12065675 | pubmed:abstractText | Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with 10 microm-0.1 mm of the compound. Co-administration of d-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP; 1 microm) to block spinal micro-opioid receptors did not modify this effect, whereas naltrindole (10 microm) totally prevented it and nor-binaltorphimine (10 microm) reduced the post-effect. These data suggest that 1DMe triggers the release of endogenous opioids that stimulate mainly delta-opioid receptors, and secondarily kappa-opioid receptors, thereby exerting a negative influence on dynorphin A (1-8)-like material outflow. Because dynorphin has pronociceptive properties, such a decrease in spinal dynorphin A (1-8)-like material release might underlie the long-lasting antinociceptive effects of intrathecally administered neuropeptide FF and analogues. | lld:pubmed |
| pubmed-article:12065675 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12065675 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065675 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12065675 | pubmed:month | May | lld:pubmed |
| pubmed-article:12065675 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:HamonMichelM | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:MauborgneAnni... | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:CesselinFranç... | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:BourgoinSylvi... | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:BalletSébasti... | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:BrazJoaoJ | lld:pubmed |
| pubmed-article:12065675 | pubmed:author | pubmed-author:ZajacJean-Mar... | lld:pubmed |
| pubmed-article:12065675 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12065675 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:12065675 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12065675 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12065675 | pubmed:pagination | 659-62 | lld:pubmed |
| pubmed-article:12065675 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12065675 | pubmed:meshHeading | pubmed-meshheading:12065675... | lld:pubmed |
| pubmed-article:12065675 | pubmed:meshHeading | pubmed-meshheading:12065675... | lld:pubmed |
| pubmed-article:12065675 | pubmed:meshHeading | pubmed-meshheading:12065675... | lld:pubmed |
| pubmed-article:12065675 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12065675 | pubmed:articleTitle | The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord. | lld:pubmed |
| pubmed-article:12065675 | pubmed:affiliation | NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, INSERM U288, Faculté de Médecine Pitié-Salpêtrière, Paris, France. | lld:pubmed |
| pubmed-article:12065675 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12065675 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
