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rdf:type |
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lifeskim:mentions |
umls-concept:C0013355,
umls-concept:C0030685,
umls-concept:C0070651,
umls-concept:C0243071,
umls-concept:C0391871,
umls-concept:C0392756,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1515655,
umls-concept:C1882864,
umls-concept:C1963578
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pubmed:issue |
3
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pubmed:dateCreated |
2002-6-14
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pubmed:abstractText |
Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with 10 microm-0.1 mm of the compound. Co-administration of d-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP; 1 microm) to block spinal micro-opioid receptors did not modify this effect, whereas naltrindole (10 microm) totally prevented it and nor-binaltorphimine (10 microm) reduced the post-effect. These data suggest that 1DMe triggers the release of endogenous opioids that stimulate mainly delta-opioid receptors, and secondarily kappa-opioid receptors, thereby exerting a negative influence on dynorphin A (1-8)-like material outflow. Because dynorphin has pronociceptive properties, such a decrease in spinal dynorphin A (1-8)-like material release might underlie the long-lasting antinociceptive effects of intrathecally administered neuropeptide FF and analogues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/dynorphin (1-8),
http://linkedlifedata.com/resource/pubmed/chemical/naltrindole,
http://linkedlifedata.com/resource/pubmed/chemical/norbinaltorphimine,
http://linkedlifedata.com/resource/pubmed/chemical/phenylalanyl-cyclo(cysteinyltyrosyl-...,
http://linkedlifedata.com/resource/pubmed/chemical/phenylalanyl-leucyl-phenylalanyl-glu...,
http://linkedlifedata.com/resource/pubmed/chemical/tyrosyl-leucyl-N-methylphenylalanyl-...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
659-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12065675-Animals,
pubmed-meshheading:12065675-Dose-Response Relationship, Drug,
pubmed-meshheading:12065675-Dynorphins,
pubmed-meshheading:12065675-Injections, Spinal,
pubmed-meshheading:12065675-Male,
pubmed-meshheading:12065675-Models, Animal,
pubmed-meshheading:12065675-Naltrexone,
pubmed-meshheading:12065675-Narcotic Antagonists,
pubmed-meshheading:12065675-Oligopeptides,
pubmed-meshheading:12065675-Peptide Fragments,
pubmed-meshheading:12065675-Perfusion,
pubmed-meshheading:12065675-Radioimmunoassay,
pubmed-meshheading:12065675-Rats,
pubmed-meshheading:12065675-Rats, Sprague-Dawley,
pubmed-meshheading:12065675-Receptors, Opioid, delta,
pubmed-meshheading:12065675-Receptors, Opioid, kappa,
pubmed-meshheading:12065675-Receptors, Opioid, mu,
pubmed-meshheading:12065675-Somatostatin,
pubmed-meshheading:12065675-Spinal Cord
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pubmed:year |
2002
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pubmed:articleTitle |
The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord.
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pubmed:affiliation |
NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, INSERM U288, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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