| pubmed-article:12065524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0887870 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0007577 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0055023 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C1519726 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C1414898 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12065524 | lifeskim:mentions | umls-concept:C2700289 | lld:lifeskim |
| pubmed-article:12065524 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12065524 | pubmed:dateCreated | 2002-6-14 | lld:pubmed |
| pubmed-article:12065524 | pubmed:abstractText | The signaling pathways triggered by adherence of Candida albicans to the host cells or extracellular matrix are poorly understood. We provide here evidence in C. albicans yeasts of a p105 focal adhesion kinase (Fak)-like protein (that we termed CaFak), antigenically related to the vertebrate p125Fak, and its involvement in integrin-like-mediated fungus adhesion to vitronectin (VN) and EA.hy 926 human endothelial cell line. Biochemical analysis with different anti-chicken Fak antibodies identified CaFak as a 105-kDa protein and immunofluorescence and cytofluorimetric analysis on permeabilized cells specifically stain C. albicans yeasts; moreover, confocal microscopy evidences CaFak as a cytosolic protein that colocalizes on the membrane with the integrin-like VN receptors upon yeast adhesion to VN. The protein tyrosine kinase (PTK) inhibitors genistein and herbimycin A strongly inhibited C. albicans yeast adhesion to VN and EA.hy 926 endothelial cells. Moreover, engagement of alpha v beta 3 and alpha v beta 5 integrin-like on C. albicans either by specific monoclonal antibodies or upon adhesion to VN or EA.hy 926 endothelial cells stimulates CaFak tyrosine phosphorylation that is blocked by PTK inhibitor. A role for CaFak in C. albicans yeast adhesion was also supported by the failure of VN to stimulate its tyrosine phosphorylation in a C. albicans mutant showing normal levels of CaFak and VNR-like integrins but displaying reduced adhesiveness to VN and EA.hy 926 endothelial cells. Our results suggest that C. albicans Fak-like protein is involved in the control of yeast cell adhesion to VN and endothelial cells. | lld:pubmed |
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| pubmed-article:12065524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12065524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12065524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12065524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12065524 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12065524 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:PiccoliMarioM | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:SantoniGiorgi... | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:LucciariniRob... | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:AmantiniConsu... | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:JacobelliJord... | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:SpreghiniElis... | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:BallariniPatr... | lld:pubmed |
| pubmed-article:12065524 | pubmed:author | pubmed-author:GismondiAngel... | lld:pubmed |
| pubmed-article:12065524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12065524 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:12065524 | pubmed:owner | NLM | lld:pubmed |
