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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-6-14
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pubmed:abstractText |
We assessed in vivo the anti-inflammatory activity of two Cat's claw bark extracts, by comparing a spray-dried hydroalcoholic extract against an aqueous freeze-dried extract, to determine which extract was more effective. We used the carrageenan-induced paw edema model in mice. In addition, to assess the molecular mechanism of action, we determined the inhibition of NF-kappa B through the Electrophoretic Mobility Shift Assay (EMSA) and the effects on cycloxygenase-1 and -2. Results showed that the anti-inflammatory activity was significantly higher using the hydroalcoholic compared with the aqueous extract (P<0.05). The extracts also showed little inhibitory activity on cyclooxygenase-1 and -2. It cannot be excluded that the slight inhibitory activity on DNA binding of NF-kappa B is due to cytotoxic effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0378-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12065162-Animals,
pubmed-meshheading:12065162-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:12065162-Cat's Claw,
pubmed-meshheading:12065162-Cyclooxygenase 1,
pubmed-meshheading:12065162-Cyclooxygenase 2,
pubmed-meshheading:12065162-Edema,
pubmed-meshheading:12065162-Enzyme Inhibitors,
pubmed-meshheading:12065162-Female,
pubmed-meshheading:12065162-Humans,
pubmed-meshheading:12065162-Isoenzymes,
pubmed-meshheading:12065162-Jurkat Cells,
pubmed-meshheading:12065162-Membrane Proteins,
pubmed-meshheading:12065162-Mice,
pubmed-meshheading:12065162-Mice, Inbred BALB C,
pubmed-meshheading:12065162-NF-kappa B,
pubmed-meshheading:12065162-Plant Bark,
pubmed-meshheading:12065162-Plant Extracts,
pubmed-meshheading:12065162-Prostaglandin-Endoperoxide Synthases
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pubmed:year |
2002
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pubmed:articleTitle |
Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).
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pubmed:affiliation |
Microbiology Department, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Apartado 4314, Lima 100, Peru. jaguilar@upch.edu.pe
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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