Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-6-13
pubmed:abstractText
E2F is a family of transcriptional factors that control G(1)/S transition. We investigated how the E2F family participates in the biological responses of vascular smooth muscle cells (VSMC) to vasoconstrictive hormones compared with fetal bovine serum (FBS). FBS induced upregulation of E2F-1 and E2F-5 at both mRNA and protein levels and slightly reduced E2F-3 protein. Angiotensin II (ANG II) and arginine vasopressin increased E2F-3 protein, but not E2F-1 and E2F-5, without upregulating its mRNA level. FBS transactivated the E2F-1 gene through the induction of free E2F-1 binding onto its promoter, whereas ANG II-induced binding of E2F-3 did not result in activation of the E2F-1 promoter. These changes are responsible for hypertrophic or hyperplastic response of VSMC to different growth factors or stimulants. In contrast, both FBS and vasoconstrictive hormones drove transcription of the cdc6 gene by downregulating p130 and recruiting free E2F-3 in the latter, which underlies the progression of VSMC into S phase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II, http://linkedlifedata.com/resource/pubmed/chemical/Arginine Vasopressin, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/E2F Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/E2F1 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/E2F2 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/E2F3 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/E2F4 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/E2F5 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/E2f1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/E2f5 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
283
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H204-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12063292-Angiotensin II, pubmed-meshheading:12063292-Animals, pubmed-meshheading:12063292-Arginine Vasopressin, pubmed-meshheading:12063292-Cell Cycle, pubmed-meshheading:12063292-Cell Cycle Proteins, pubmed-meshheading:12063292-Cell Division, pubmed-meshheading:12063292-Cells, Cultured, pubmed-meshheading:12063292-DNA-Binding Proteins, pubmed-meshheading:12063292-E2F Transcription Factors, pubmed-meshheading:12063292-E2F1 Transcription Factor, pubmed-meshheading:12063292-E2F2 Transcription Factor, pubmed-meshheading:12063292-E2F3 Transcription Factor, pubmed-meshheading:12063292-E2F4 Transcription Factor, pubmed-meshheading:12063292-E2F5 Transcription Factor, pubmed-meshheading:12063292-Male, pubmed-meshheading:12063292-Muscle, Smooth, Vascular, pubmed-meshheading:12063292-Protein Subunits, pubmed-meshheading:12063292-RNA, Messenger, pubmed-meshheading:12063292-Rats, pubmed-meshheading:12063292-Rats, Sprague-Dawley, pubmed-meshheading:12063292-Transcription Factors, pubmed-meshheading:12063292-Vasoconstrictor Agents
pubmed:year
2002
pubmed:articleTitle
Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells.
pubmed:affiliation
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't