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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-6-13
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pubmed:abstractText |
Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
639-49
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12062106-Amino Acid Motifs,
pubmed-meshheading:12062106-Animals,
pubmed-meshheading:12062106-Bodily Secretions,
pubmed-meshheading:12062106-Caenorhabditis elegans,
pubmed-meshheading:12062106-Caenorhabditis elegans Proteins,
pubmed-meshheading:12062106-Evolution, Molecular,
pubmed-meshheading:12062106-Gene Expression Regulation,
pubmed-meshheading:12062106-Homeodomain Proteins,
pubmed-meshheading:12062106-Learning,
pubmed-meshheading:12062106-Nerve Tissue Proteins,
pubmed-meshheading:12062106-Nervous System,
pubmed-meshheading:12062106-Neural Pathways,
pubmed-meshheading:12062106-Neurons,
pubmed-meshheading:12062106-Neuropeptides,
pubmed-meshheading:12062106-Phenotype,
pubmed-meshheading:12062106-Phylogeny,
pubmed-meshheading:12062106-Receptors, LDL,
pubmed-meshheading:12062106-Sensation,
pubmed-meshheading:12062106-Signal Transduction
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pubmed:year |
2002
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pubmed:articleTitle |
HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans.
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pubmed:affiliation |
Structural Biology Center, National Institute of Genetics, Mishima, Japan. tishihar@lab.nig.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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