Linked Life Data

12061499

Source:http://linkedlifedata.com/resource/pubmed/id/12061499

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-6-13
pubmed:abstractText
Schwann cells that have myelinated the CNS can be replaced by myelinating oligodendrocytes. It is unclear, however, why oligodendrocyte remyelination would occur for axons that are already myelinated. The Schwann cells might signal their own replacement by oligodendrocytes, but more probably a third player, the reactive astrocyte, is essential to this phenomenon. We propose that as long as reactive astrocytes do not form fibrous gliosis, they are beneficial to oligodendrocyte remyelination. Unknown is whether reactive astrocytes induce oligodendrocyte progenitor (NG2 immunopositive cells) cells to differentiate, a phenomenon that is absent in multiple sclerosis. So what role do Schwann cells play in CNS remyelination? They appear to serve to protect central axons and might coincidentally prevent reactive astrocytes from laying down scar tissue that impedes oligodendrocyte remyelination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1073-8584
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
198-203
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Remyelination within the CNS: do schwann cells pave the way for oligodendrocytes?
pubmed:affiliation
Department of Neurological Surgery, University of California, San Francisco, 94143-0452, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't