Linked Life Data

12061141

Source:http://linkedlifedata.com/resource/pubmed/id/12061141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-6-13
pubmed:abstractText
Neuronal nicotinic acetylcholine receptors (nAChR) are a family of ligand-gated ion channels that have a pentameric structure composed of five membrane spanning subunits. Recent progress in clinical and neurochemical studies have shown that neuronal nAChR are involved in some psychiatric disorders such as schizophrenia, depression, and anxiety via its stimulating effect of multiple neurotransmitters. It has been suggested that the high prevalence of smoking in the patients with psychiatric disorders is an attempt to alleviate some psychiatric symptoms using the central stimulatory effect of nicotine (a self-medication effort) or to alleviate the exacerbated symptoms by nicotine withdrawal. Moreover, recent studies with mutant mice lacking specific nAChR subunits and animal models of psychiatric disorders have indicated the psychopharmacological role of individual nAChR subunits in psychiatric disorders. Thus, it is suggested that alpha 7 nAChR is involved in the attention deficit of schizophrenic patients and that alpha 4 beta 2 nAChR is related to nicotine dependence or the withdrawal symptoms.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0015-5691
pubmed:author
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-300
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Involvement of neuronal nicotinic receptor in psychiatric disorders].
pubmed:affiliation
Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. suemaru@cc.okayama-u.ac.jp
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't