| pubmed-article:12060693 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12060693 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12060693 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:12060693 | lifeskim:mentions | umls-concept:C0752046 | lld:lifeskim |
| pubmed-article:12060693 | lifeskim:mentions | umls-concept:C0182400 | lld:lifeskim |
| pubmed-article:12060693 | lifeskim:mentions | umls-concept:C1519193 | lld:lifeskim |
| pubmed-article:12060693 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12060693 | pubmed:dateCreated | 2002-6-12 | lld:pubmed |
| pubmed-article:12060693 | pubmed:abstractText | Single nucleotide polymorphisms are implicated as having a significant role in regulating growth, development and, thereby, human health and disease. We have developed a method for identifying single nucleotide genetic alterations by combining hairpin-forming DNA probes and electrochemical detection of sandwich DNA hybridization. Incorporation of hairpin-forming competitor probes and the catalyzed reporter deposition amplification system further improves assay specificity by 7-fold and sensitivity by 100-fold. We have demonstrated that the system successfully identified the factor V Leiden mutations from human blood specimens. | lld:pubmed |
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| pubmed-article:12060693 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12060693 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12060693 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12060693 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12060693 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:12060693 | pubmed:author | pubmed-author:MillerJeff... | lld:pubmed |
| pubmed-article:12060693 | pubmed:author | pubmed-author:LiuMinghsunM | lld:pubmed |
| pubmed-article:12060693 | pubmed:author | pubmed-author:GrodyWayne... | lld:pubmed |
| pubmed-article:12060693 | pubmed:author | pubmed-author:HuangTony... | lld:pubmed |
| pubmed-article:12060693 | pubmed:author | pubmed-author:KnightLinda... | lld:pubmed |
| pubmed-article:12060693 | pubmed:author | pubmed-author:HoChih-MingCM | lld:pubmed |
| pubmed-article:12060693 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12060693 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12060693 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:12060693 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12060693 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12060693 | pubmed:pagination | e55 | lld:pubmed |
| pubmed-article:12060693 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12060693 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12060693 | pubmed:articleTitle | An electrochemical detection scheme for identification of single nucleotide polymorphisms using hairpin-forming probes. | lld:pubmed |
| pubmed-article:12060693 | pubmed:affiliation | Mechanical and Aerospace Engineering Department, University of California-Los Angeles, Los Angeles, CA 90095-1597, USA. | lld:pubmed |
| pubmed-article:12060693 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12060693 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12060693 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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