Source:http://linkedlifedata.com/resource/pubmed/id/12060636
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-6-12
|
| pubmed:abstractText |
Several barriers that collectively restrict gene delivery by viral vectors in vivo have been described. Previously, we identified soluble chondroitin sulfate-proteoglycans/glycosaminoglycans in malignant pleural effusions (MPEs) as inhibitors of retroviral vector transduction. Soluble components of MPE also inhibited adenoviral (Ad) gene transfer, and the factors were characteristically filterable, titrable, stable at 56 degrees C, and blocked the binding of Ad to target cells. Depleting immunoglobulin from MPE, partially reversed the block to Ad transduction, instigating a search for additional factors that bound Ad in MPE.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1078-0432
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1915-23
|
| pubmed:dateRevised |
2011-7-1
|
| pubmed:meshHeading |
pubmed-meshheading:12060636-Adenoviridae,
pubmed-meshheading:12060636-Animals,
pubmed-meshheading:12060636-Antibodies, Monoclonal,
pubmed-meshheading:12060636-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:12060636-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:12060636-Enterovirus,
pubmed-meshheading:12060636-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12060636-Gene Expression,
pubmed-meshheading:12060636-Gene Therapy,
pubmed-meshheading:12060636-Gene Transfer Techniques,
pubmed-meshheading:12060636-Genetic Vectors,
pubmed-meshheading:12060636-Humans,
pubmed-meshheading:12060636-Lac Operon,
pubmed-meshheading:12060636-Lung Neoplasms,
pubmed-meshheading:12060636-Mice,
pubmed-meshheading:12060636-Pleural Effusion,
pubmed-meshheading:12060636-Receptors, Virus,
pubmed-meshheading:12060636-Tumor Cells, Cultured
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Soluble coxsackievirus adenovirus receptor is a putative inhibitor of adenoviral gene transfer in the tumor milieu.
|
| pubmed:affiliation |
Department of Medicine, The University of California at Los Angeles (UCLA)/ Wadsworth Pulmonary Immunology and Gene Medicine Laboratory, Los Angeles, CA 90073, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|