rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
2002-6-11
|
pubmed:abstractText |
The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) with a median seizure reduction of 21%. Eighty percent of patients had fewer seizures on talampanel than on placebo. Dizziness (52%) and ataxia (26%) were the only significant adverse events.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0028-3878
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
11
|
pubmed:volume |
58
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1680-2
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12058100-Adult,
pubmed-meshheading:12058100-Anticonvulsants,
pubmed-meshheading:12058100-Benzodiazepines,
pubmed-meshheading:12058100-Carbamazepine,
pubmed-meshheading:12058100-Cross-Over Studies,
pubmed-meshheading:12058100-Double-Blind Method,
pubmed-meshheading:12058100-Drug Therapy, Combination,
pubmed-meshheading:12058100-Epilepsies, Partial,
pubmed-meshheading:12058100-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12058100-Female,
pubmed-meshheading:12058100-Humans,
pubmed-meshheading:12058100-Male,
pubmed-meshheading:12058100-Middle Aged,
pubmed-meshheading:12058100-Treatment Outcome,
pubmed-meshheading:12058100-Valproic Acid
|
pubmed:year |
2002
|
pubmed:articleTitle |
A crossover, add-on trial of talampanel in patients with refractory partial seizures.
|
pubmed:affiliation |
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. aschappell@lilly.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
|