Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-6-11
pubmed:abstractText
It is generally believed that active invasion by cancer cells is essential to the metastatic process. In this report, we describe a murine mammary tumor (MCH66) model of metastasis that does not require invasion into the vascular wall of both the primary tumor and the target organ, in this case, the lung. The process involves intravasation of tumor nests surrounded by sinusoidal blood vessels, followed by intravascular tumor growth in the lung, without penetration of the vascular wall during the process. Comparative studies using a nonmetastatic MCH66 clone (MCH66C8) and another highly invasive metastatic cell line (MCH416) suggested that high angiogenic activity and sinusoidal remodeling of tumor blood vessels were prerequisites for MCH66 metastasis. Differential cDNA analysis identified several genes that were overexpressed by MCH66, including genes for the angiogenesis factor pleiotrophin, and extracellular matrix-associated molecules that may modulate the microenvironment toward neovascularization. Our analyses suggest that tumor angiogenesis plays a role in the induction of invasion-independent metastasis. This model should prove useful in screening and development of new therapeutic agents for cancer metastasis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-10224097, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-10428823, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-12057896, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-1378165, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-1712071, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-3277442, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-4787857, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-6639858, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-7516992, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-7688351, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-8063762, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-8167412, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-8175719, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-9083061, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-9500469, http://linkedlifedata.com/resource/pubmed/commentcorrection/12057902-9927484
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1973-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
An invasion-independent pathway of blood-borne metastasis: a new murine mammary tumor model.
pubmed:affiliation
Department of Pathology, School of Medicine, Fukushima Medical University, Fukushima City, Japan. sugino@fmu.ac.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't