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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-6-11
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pubmed:abstractText |
The suitability of 4-di(2-chloroethyl)aminoanilino-4-hydroxyphenethylaminomethanone 2 to act as a prodrug for melanocyte-directed enzyme prodrug therapy (MDEPT) is assessed. Thus its synthesis, ability to generate a cytotoxic agent upon exposure to tyrosinase, and stability within different sera are reported. A comparison is made to illustrate that the new urea prodrug 2 is a more suitable candidate for MDEPT than the corresponding carbamate prodrug 1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0968-0896
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2625-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12057651-Animals,
pubmed-meshheading:12057651-Blood,
pubmed-meshheading:12057651-Carbamates,
pubmed-meshheading:12057651-Cattle,
pubmed-meshheading:12057651-Cell Death,
pubmed-meshheading:12057651-Drug Delivery Systems,
pubmed-meshheading:12057651-Drug Stability,
pubmed-meshheading:12057651-Enzymes,
pubmed-meshheading:12057651-Humans,
pubmed-meshheading:12057651-Melanocytes,
pubmed-meshheading:12057651-Monophenol Monooxygenase,
pubmed-meshheading:12057651-Prodrugs,
pubmed-meshheading:12057651-Urea
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT).
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pubmed:affiliation |
Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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