Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-6-11
pubmed:abstractText
Primary central nervous system lymphoma (PCNSL) is widely regarded as one of the primary brain tumors most amenable to treatment. Although whole brain radiotherapy was the cornerstone of therapy for decades, recent work clearly indicates that chemotherapy has become the primary focus of treatment for this disease. The initial treatment of PCNSL for all patients, including the elderly, should be chemotherapy using a high-dose methotrexate-based regimen. Although cranial irradiation has often been combined with methotrexate, the unacceptably high incidence of late neurotoxicity, particularly in older patients, has caused many to eliminate radiotherapy, especially in those older than age 60 years. Emerging data support the validity of this approach, and the development of more efficacious chemotherapeutic regimens has been the focus of recent research.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1527-2729
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-18
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed-meshheading:12057111-Adrenal Cortex Hormones, pubmed-meshheading:12057111-Adult, pubmed-meshheading:12057111-Aged, pubmed-meshheading:12057111-Anticonvulsants, pubmed-meshheading:12057111-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:12057111-Biopsy, pubmed-meshheading:12057111-Brain Neoplasms, pubmed-meshheading:12057111-Combined Modality Therapy, pubmed-meshheading:12057111-Cranial Irradiation, pubmed-meshheading:12057111-Craniotomy, pubmed-meshheading:12057111-Diagnostic Imaging, pubmed-meshheading:12057111-Eye, pubmed-meshheading:12057111-Humans, pubmed-meshheading:12057111-Injections, Spinal, pubmed-meshheading:12057111-Lymphoma, AIDS-Related, pubmed-meshheading:12057111-Lymphoma, Non-Hodgkin, pubmed-meshheading:12057111-Meninges, pubmed-meshheading:12057111-Methotrexate, pubmed-meshheading:12057111-Middle Aged, pubmed-meshheading:12057111-Neoplasm Invasiveness, pubmed-meshheading:12057111-Seizures, pubmed-meshheading:12057111-Stereotaxic Techniques, pubmed-meshheading:12057111-Survival Analysis, pubmed-meshheading:12057111-Treatment Outcome, pubmed-meshheading:12057111-Vitrectomy
pubmed:year
2001
pubmed:articleTitle
Primary central nervous system lymphomas.
pubmed:affiliation
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021-6700, USA. deangell@mskcc.org
pubmed:publicationType
Journal Article, Review