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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-10-29
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pubmed:abstractText |
We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10348225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10447880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10468555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10470037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10898682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10905260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-10983555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-11130385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-11493411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-11528574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-1314606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-394674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-8116812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-8651372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-9020100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12057021-9129535
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1475-2875
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12057021-Amino Acid Substitution,
pubmed-meshheading:12057021-Animals,
pubmed-meshheading:12057021-Antimalarials,
pubmed-meshheading:12057021-Atovaquone,
pubmed-meshheading:12057021-Codon,
pubmed-meshheading:12057021-Cytochromes b,
pubmed-meshheading:12057021-Drug Combinations,
pubmed-meshheading:12057021-Drug Resistance,
pubmed-meshheading:12057021-Humans,
pubmed-meshheading:12057021-London,
pubmed-meshheading:12057021-Malaria, Falciparum,
pubmed-meshheading:12057021-Male,
pubmed-meshheading:12057021-Middle Aged,
pubmed-meshheading:12057021-Mutation, Missense,
pubmed-meshheading:12057021-Naphthoquinones,
pubmed-meshheading:12057021-Nigeria,
pubmed-meshheading:12057021-Parasitemia,
pubmed-meshheading:12057021-Plasmodium falciparum,
pubmed-meshheading:12057021-Proguanil,
pubmed-meshheading:12057021-Protozoan Proteins,
pubmed-meshheading:12057021-Travel
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pubmed:year |
2002
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pubmed:articleTitle |
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria.
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pubmed:affiliation |
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. quinton.fivelman@lshtm.ac.uk
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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