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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-6-10
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pubmed:abstractText |
The immune response against the intracellular bacterium Listeria monocytogenes involves both CD4(+) and CD8(+) T cells. We used the MHC class II-presented peptide listeriolysin(189-201) to characterize the organ-specific CD4(+) T cell response during infection. Systemic listeriosis resulted in a strong peptide-specific CD4(+) T cell response with frequencies of 1/100 and 1/30 CD4(+) splenocytes at the peak of primary and secondary response, respectively. This response was not restricted to lymphoid organs, because we detected specific CD4(+) T cells in all tissues analyzed. However, the tissue distribution of the T cell response was dependent on the route of infection. After i.v. infection, the strongest CD4(+) T cell response and the highest levels of memory cells were observed in spleen and liver, the major sites of L. monocytogenes replication. After oral infection, we detected a strong response in the liver, the lamina propria, and the intestinal epithelium. These tissues also harbored the highest frequencies of listeriolysin(189-201)-specific CD4(+) memory T cells 5-8 wk post oral infection. Our results show that kinetics and magnitude of the CD4(+) T cell response and the accumulation of CD4(+) memory T cells depend on the route of infection and are regulated in a tissue-specific way.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemolysin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/hlyA protein, Listeria monocytogenes
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6382-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12055256-Administration, Oral,
pubmed-meshheading:12055256-Animals,
pubmed-meshheading:12055256-Antigens, Bacterial,
pubmed-meshheading:12055256-Bacterial Toxins,
pubmed-meshheading:12055256-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12055256-Cells, Cultured,
pubmed-meshheading:12055256-Cytokines,
pubmed-meshheading:12055256-Epitopes, T-Lymphocyte,
pubmed-meshheading:12055256-Heat-Shock Proteins,
pubmed-meshheading:12055256-Hemolysin Proteins,
pubmed-meshheading:12055256-Immunologic Memory,
pubmed-meshheading:12055256-Injections, Intravenous,
pubmed-meshheading:12055256-Interferon-gamma,
pubmed-meshheading:12055256-Intestine, Small,
pubmed-meshheading:12055256-Intubation, Gastrointestinal,
pubmed-meshheading:12055256-Kinetics,
pubmed-meshheading:12055256-Listeria monocytogenes,
pubmed-meshheading:12055256-Listeriosis,
pubmed-meshheading:12055256-Liver,
pubmed-meshheading:12055256-Mice,
pubmed-meshheading:12055256-Mice, Inbred C57BL,
pubmed-meshheading:12055256-Organ Specificity,
pubmed-meshheading:12055256-Spleen,
pubmed-meshheading:12055256-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Organ-specific CD4+ T cell response during Listeria monocytogenes infection.
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pubmed:affiliation |
Max-Planck-Institute for Infection Biology, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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