Linked Life Data

12054691

Source:http://linkedlifedata.com/resource/pubmed/id/12054691

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pubmed-article:12054691pubmed:abstractTextBiochemical and immunohistochemical evidence is reported, showing basal protein nitration in specific regions of the optic lobes of Sepia officinalis, mainly in the fiber layers of the plexiform zone. SDS-PAGE analysis of optic lobe extracts revealed an intense 3-nitrotyrosine immunoreactive band identified as alpha-tubulin by immunoprecipitation and partial purification. Stimulation of NMDA receptors resulted in a selective decrease in alpha-tubulin levels within 30 min with partial recovery after 4 h. The effect was suppressed by the NO synthase (NOS) inhibitor L-nitroarginine. Incubation of optic lobes with free 3-nitrotyrosine resulted likewise in a selective loss of alpha-tubulin, due apparently to incorporation of the amino acid into the C-terminus of detyrosinated alpha-tubulin to give the nitrated protein purportedly more susceptible to degradation. Overall, these results point to a novel potential physiologic role of NO and free 3-nitrotyrosine in the control of the alpha-tubulin tyrosination/detyrosination cycle and turnover in Sepia nervous tissue.lld:pubmed
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pubmed-article:12054691pubmed:authorpubmed-author:PalumboAnnaAlld:pubmed
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pubmed-article:12054691pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:12054691pubmed:year2002lld:pubmed
pubmed-article:12054691pubmed:articleTitleNMDA receptor stimulation induces temporary alpha-tubulin degradation signaled by nitric oxide-mediated tyrosine nitration in the nervous system of Sepia officinalis.lld:pubmed
pubmed-article:12054691pubmed:affiliationZoological Station Anton Dohrn, Villa Comunale, I-80121, Naples, Italy. palumbo@alpha.szn.itlld:pubmed
pubmed-article:12054691pubmed:publicationTypeJournal Articlelld:pubmed
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