|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0020792,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0035696,
umls-concept:C0205419,
umls-concept:C0534858,
umls-concept:C0597298,
umls-concept:C0679058,
umls-concept:C1514562,
umls-concept:C1547699,
umls-concept:C1707271,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2700640
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2002-6-10
|
|
pubmed:abstractText |
We identified a splice variant of mouse caveolin-2 mRNA having an intronic sequence in place of the third exon (Deltaex3). The entire sequence of full-length (FL) and Deltaex3 caveolin-2 mRNA was determined; their sizes were 2490 and 973 bp, respectively. The Deltaex3 mRNA encoded a putative isoform lacking the C-terminal 49 amino acids of the authentic caveolin-2. The expression level of Deltaex3 was lower than that of FL mRNA, but considerable in some culture cells and tissues. The isoform lacking the C-terminus localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1. The result confirmed the necessity of the C-terminal domain of caveolin-2 for the caveolar localization, and showed the existence of a novel caveolin-2 isoform, which is not recruited to caveolae even in the presence of caveolin-1.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0003-9861
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
(c) 2002 Elsevier Science (USA).
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
401
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
108-14
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12054493-3T3 Cells,
pubmed-meshheading:12054493-Alternative Splicing,
pubmed-meshheading:12054493-Amino Acid Sequence,
pubmed-meshheading:12054493-Animals,
pubmed-meshheading:12054493-Base Sequence,
pubmed-meshheading:12054493-Caveolae,
pubmed-meshheading:12054493-Caveolin 1,
pubmed-meshheading:12054493-Caveolin 2,
pubmed-meshheading:12054493-Caveolins,
pubmed-meshheading:12054493-Cell Line,
pubmed-meshheading:12054493-Cell Membrane,
pubmed-meshheading:12054493-Endoplasmic Reticulum,
pubmed-meshheading:12054493-Exons,
pubmed-meshheading:12054493-Golgi Apparatus,
pubmed-meshheading:12054493-Introns,
pubmed-meshheading:12054493-Male,
pubmed-meshheading:12054493-Mice,
pubmed-meshheading:12054493-Protein Structure, Tertiary,
pubmed-meshheading:12054493-RNA, Messenger,
pubmed-meshheading:12054493-Tissue Distribution
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Identification of a splice variant of mouse caveolin-2 mRNA encoding an isoform lacking the C-terminal domain.
|
|
pubmed:affiliation |
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Showa-ku, 466-8550, Japan. hkogo@med.nagoya-u.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
