Linked Life Data

12054096

Source:http://linkedlifedata.com/resource/pubmed/id/12054096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-6-10
pubmed:abstractText
Antidepressants exhibit a number of pharmacological mechanisms, including norepinephrine and serotonin modulation, direct and indirect effects on opioid receptors, inhibition of histamine, cholinergic and N-methyl-D-aspartate receptors, and inhibition of ion channel activity. Although it is not entirely clear which mechanisms produce analgesia and to what extent, the available animal and clinical trials data indicates that tricyclic antidepressants are effective in treating many types of pain. The newer selective serotonin reuptake inhibitors also appear to be effective for chronic headache and other non-neuropathic forms of chronic pain but are not as well studied. This article reviews the current basic and clinical research on antidepressants in pain management.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1472-4472
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
454-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Antidepressants in pain management.
pubmed:affiliation
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle 98195, USA. gtcarter@u.washington.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review