Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-6-7
pubmed:abstractText
High blood pressure is a predictor of cardiovascular disease. Hence, genes contributing to essential hypertension may play a role in the etiology of cardiovascular disease. For this reason, we examined the association between the alpha-adducin (ADD1) G460W and G-protein beta3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study. PAD prevalence was defined by an ankle-brachial index, ie, the ratio of ankle systolic blood pressure to brachial artery systolic blood pressure, of </=0.90 for men and </=0.85 for women. CHD incidence was determined by following the ARIC cohort for a median of 5.3 years for potential coronary events. Stratified random samples of the ARIC cohort (n=703 and n=684) were used, respectively, as the comparison groups for the PAD (n=144) and incident CHD (n=408) cases. The GNB3 825T allele and the ADD1 460W allele were not significantly associated with prevalence of PAD or incidence of CHD. However, a test of the interaction between hypertension status and the ADD1 G460W polymorphism indicated that further evaluation of the ADD1 polymorphism in only hypertensive individuals was warranted. The ADD1 460W allele was significantly associated with PAD (odds ratio [OR]: 2.61, 95% CI, 1.27-5.37, P=0.01) and CHD (hazard rate ratio [HRR]: 2.30, 95% CI, 1.20-4.42, P=0.01) in hypertensive individuals after adjustment for multiple cardiovascular disease risk factors. An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1053-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12052841-Alleles, pubmed-meshheading:12052841-Arterial Occlusive Diseases, pubmed-meshheading:12052841-Calmodulin-Binding Proteins, pubmed-meshheading:12052841-Cardiovascular Diseases, pubmed-meshheading:12052841-Case-Control Studies, pubmed-meshheading:12052841-Coronary Disease, pubmed-meshheading:12052841-European Continental Ancestry Group, pubmed-meshheading:12052841-Female, pubmed-meshheading:12052841-Gene Frequency, pubmed-meshheading:12052841-Genetic Predisposition to Disease, pubmed-meshheading:12052841-Genotype, pubmed-meshheading:12052841-Heterotrimeric GTP-Binding Proteins, pubmed-meshheading:12052841-Humans, pubmed-meshheading:12052841-Hypertension, pubmed-meshheading:12052841-Incidence, pubmed-meshheading:12052841-Male, pubmed-meshheading:12052841-Middle Aged, pubmed-meshheading:12052841-Polymorphism, Single Nucleotide, pubmed-meshheading:12052841-Prevalence
pubmed:year
2002
pubmed:articleTitle
ADD1 460W allele associated with cardiovascular disease in hypertensive individuals.
pubmed:affiliation
Human Genetics Center, University of Texas-Houston Health Science Center, Houston, Tex 77030, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Multicenter Study