Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-6-7
pubmed:abstractText
Fusion is essential for mitochondrial function in a great variety of eukaryotic cell types. Yeast cells defective in mitohondrial fusion are respiration-deficient, human cells use complementation of fused mitochondria as a defence against the accumulation of oxidative damage during cellular aging and fusion is required to build an intracellular mitochondrial continuum that allows the dissipation of energy in the cell. Moreover, developmental processes such as spermatogenesis in Drosophila require regulated mitochondrial fusion. Some of the molecular mediators of mitochondrial membrane fusion have been identified in recent years. An evolutionarily conserved large GTPase in the outer membrane is essential for mitochondrial fusion, and genetic screens in yeast are revealing an increasing number of additional important genes. Mechanistic studies have provided the first insights into how the problem of faithfully fusing a double membrane-bounded organelle in a coordinated manner is solved.
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1469-221X
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
527-31
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion.
pubmed:affiliation
Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D-81377 München, Germany. benedikt.westermann@bio.med.uni-muenchen.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't