Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-6-7
pubmed:abstractText
Recent investigations in human anorectic patients indicated changes of brain choline metabolism. We used starved rats to investigate possible changes of brain choline metabolites during severe weight loss. Reductions of body weight by 15, 30 and 45% resulted in significant decreases of cerebral phosphatidylcholine and sphingomyelin levels. Concomitantly, the brain tissue content of glycerophosphocholine was increased while phosphocholine and free choline were unchanged. We conclude that severe weight loss is accompanied by phospholipase activation and breakdown of choline-containing phospholipids in the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
326
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Breakdown of choline-containing phospholipids in rat brain during severe weight loss.
pubmed:affiliation
Central Institute of Mental Health, Department of Child and Adolescent Psychiatry, Mannheim, Germany.
pubmed:publicationType
Journal Article