Source:http://linkedlifedata.com/resource/pubmed/id/12052484
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-6-7
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pubmed:abstractText |
The relationship of activated factor XII (FXIIa) and FXII 46C>T genotype to coronary atherosclerosis and endothelial function was examined in 192 randomly sampled subjects from the general population and 190 type 1 diabetic subjects (mean age 38+/-4 years). Coronary artery calcification (CAC) was measured using Electron beam CT. von Willebrand factor (vWF), a marker of endothelial function, and FXIIa were measured by ELISA. Endothelial nitric oxide production was quantified as the forearm blood flow response to intra-brachial infusion of bradykinin and N(G) monomethyl-L-arginine (L-NMMA). A higher FXIIa was independently associated with higher triglycerides (P<0.001), BMI (P=0.001), alcohol consumption (P=0.003) and vWF (P<0.001) in non-diabetic subjects and with insulin dose (P=0.009), total cholesterol (P=0.02) and alcohol (P<0.001) in diabetic subjects. Diabetic subjects had lower FXIIa (1.55 ng/ml) than non-diabetic subjects (1.92 ng/ml, P<0.001). Higher FXIIa was associated with lower response to bradykinin (P=0.048) and to L-NMMA (P=0.029). FXIIa was positively associated with CAC (odds ratio=1.57 for every 1 ng/ml higher FXIIa, P=0.005) but not independently of other risk factors (odds ratio=1.1 on adjustment). 46C>T genotype explained 18% of the variance in FXIIa (P<0.001) but was not associated with CAC (P=0.6). We conclude that plasma FXIIa is under strong genetic control but also reflects plasma triglycerides and endothelial activation or dysfunction. FXIIa appears unlikely to be directly atherogenic but may be a useful marker of coronary atherosclerosis because of its association with these other factors. Type 1 diabetes is associated with lower levels of FXIIa despite a greater prevalence of atherosclerosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
363-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12052484-Adult,
pubmed-meshheading:12052484-Biological Markers,
pubmed-meshheading:12052484-Calcinosis,
pubmed-meshheading:12052484-Coronary Artery Disease,
pubmed-meshheading:12052484-Coronary Disease,
pubmed-meshheading:12052484-Diabetes Mellitus, Type 1,
pubmed-meshheading:12052484-Endothelium, Vascular,
pubmed-meshheading:12052484-Factor XIIa,
pubmed-meshheading:12052484-Female,
pubmed-meshheading:12052484-Genotype,
pubmed-meshheading:12052484-Humans,
pubmed-meshheading:12052484-Male,
pubmed-meshheading:12052484-Nitric Oxide,
pubmed-meshheading:12052484-Polymorphism, Genetic,
pubmed-meshheading:12052484-Random Allocation,
pubmed-meshheading:12052484-Risk
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pubmed:year |
2002
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pubmed:articleTitle |
Activated factor XII levels and factor XII 46C>T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects.
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pubmed:affiliation |
Department of Epidemiology and Public Health, EURODIAB, Royal Free and University College London Medical School, 1-19 Torrington Place, UK. helen@public-health.ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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